The Relationship Between The Level Of NO And Syndrome Of Blood Stasis In Patients With Diabetic Peripheral Neuropathy

Objective:To investigate the relationship of NO levels and diabetic peripheral neuropathy (DPN),and its distribution in the different types of TCM syndromes. As well as the relationship between C-reactive protein and body mass index (BMI),fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), blood lipid and blood pressure. It may provide a reference for the objective of TCM syndromes.Methods:69 patients with type 2 DPN, and 38 patients without type 2 DPN were collected. Patients with type 2 DPN were divided into 2 groups by syndromes:blood stasis group 34 cases, blood stasis 35 cases. Patients's data, including sex, age, collected, course of disease, BMI, FBG, HbAlc, indexes related to blood lipid (TC, TG, HDL-C, LDL-C, LP, Apo A, Apo B, Apo E)and SBP, DBP, was analyzed and compared.Result:Serum NO levels in the diabetic group was significantly higher than that of diabetic peripheral neuropathy group, and difference have statistically significant (P<0.05). Compared with blood stasis group, serum NO, BMI, HbAlc, HDL-C in No-blood stasis group was higher, have statistically significant (P<0.05). Compared with No-blood stasis group, there were significantly higher in HDL-C and Apo A, longer course of disease(P<0.05). Using linear regression analysis,in type 2 diabetes,taking NO as dependent; variable,age, disease duration, BMI, FBG, HbAlc. systolic blood pressure, diastolic blood pressure, TC, TG, HDL-C, LDL-C, LP, Apo A, Apo B, Apo E. duration and HbAlc levels and NO showed a linear dependence.NO level of DPN with the duration was significantly negatively correlated by multiple regression analysis between Serum NO of DPN and age, disease duration, BMI, FBG, HbAlc,JC, TG, HDL-C, LDL-C, LP, Apo A, Apo B, Apo E, SBP, DBP..Conclusions:Serum NO may be a key for DPN pathogensis, and an objective index in diagnosising syndrome of blood stasis for clinic.