Clinical Observation Of Yiqi Huoxue Tongluo Method Combined Mecobalamin In Treatment Of Diabetic Peripheral Neuropathy

Objective Using the measure of supplementing qi and circulating blood and Meridians ways associate with Methylcobalamin remeding the peripheral neuropathy of the diabetic which furnish an availability means for the clinical doctor of DPN by practitioner of Chinese medicine.Methods The subject investigated which were the internal secretion clinic patients from hospital of Chinese medicine,the suffers with diabetic of pathological changes of nurve, which were selected for the analysis by TCM,60 cases of qi deficiency and blood stasis type syndrome were conclued by differentiation of traditional Chinese medicine,the whole of the internal secretion patients,which were stochastic block sort of measures,were splited into a cross reference group and a treatment group, and to be selected Diabetes foundation treatment.In a cross reference group:the patients were given treatment by Mecobalamin, 0.5mg po tid;In the treatment group applying the measure of supplementing qi and circulating blood and Meridians ways associate withMethylcobalamin, remeding the peripheral neuropathy of the diabetic on the under structure of the cross reference group,:astragalus, codonopsis root, angelica, millettla, herb,scrophulariaceae, cassia twig, peony, licorice, so on and so forth. 200 ml bid treatment, the twelve weeks were surving to the whole of the clinic patients,To survey the clinical of the utility, When it was over of TCM remedy, the glucose of the blood,the lipid of the biood glycosylated hemoglobin, rheology of the blood,the nerve conduction speed,Toronto clinical scoring systemand the change of parameters and safety.Results ①In the total efficiency, the treatment group of the whole effective more usefull than that of the control group in the total efficiency,and the difference of the significancy by the T test of(P<O.05), outstandingly still further usefull than the control group in the rapeutic group,which state clearly that Yi qi and activating blood circulation and the measure of Tong-luo combined with methylcobalamin was a really therapeutic method in the treatment of DPN(P<O.05).②In principal symptoms of accumulate points of traditional Chinese medical science, under the treatment of the double sets of accumulate points of traditional Chinese medical science,were remarkablely cut down(P<O.05);the groups than before. Statistical tests shows the results have statistical After therapy, the main symptoms which have reducement in the Symptom scores than the other group(P<O.05 points);That the two groups were able to laxationing the clinical symptoms in DPN patients the treatment group in improving the lower extremitynumbness pain,Sense of feeling like antwalking, ense of feeling subsided,hyperalgesia, dizziness, limbpain,the effect was moreusefull than that of the control group.③In two sets of the blood of the glucose and the blood of fat, Glycosylated hemoglobin, the whole of all the patients after curing,the blood of the glucose and glycosylated hemoglobin were cut down the above indexes before and after treatment showed no understandly difference(P>0.05);blood lipid after treatment notablely transform, Compared with the before of treatment,with statistical difference had markedness bearing(*P<O.05);a cross reference group had no ameliorate ment of blood lipids.④In the main indices of hemorheology, major indexes of the two groups blood viscosity(low shear whole blood viscosity,whole blood high shear viscosity, plasma viscosity)were decreased.compared before and after treatment, the control group in the above indexes had some significant difference(**P<O.05),there were more significant differences in the above indexes in treatment group(*P<0.01), the treatment group was still further usefull than the a cross reference group, which make known that the treatment group had good effect in improving the blood rheology of patients with DPN.⑤In the course of the nerve of transmission of speed,compared with before of treatment with after treatment,two groups of MNCV,the nerve of transmission of speed were prominent enhance(*P<0.05),control the rate of increase in SNCV treatment group was more usefull than that of MNCV(P<0.05),which make known that,the treatment group in the improvement of patients with DPN, had good effect on nerve conduction of speed.⑥In Toronto score comparison, compared remedy with prior treatment, two groups of nerve lesion scores were prominentl fall(P<O.05), make clear that, the effect of treatment in the doule groups of patients,with nurve of Pathological changes of the points were depress; afterthe remedy, the two groups were compared distinguish the treatment group neuropathy score lower than that of a cross reference set, Statistical analysis showing the difference which was statistically significant(P<0.05).⑦In the side of security,the safety index of two groups,have no obvious unusual condition off spring the remedy,which make known that the two groups of treatment was safe and feasible.Conclusions Using the measure of supplementing qi and circulating blood and Meridians ways associate with Methylcobalamin remeding the peripheral neuropathy of the diabetic which furnish an availability means for the clinical doctor of DPN,can make the patients clinical symptoms and signs transform;remarkable,the glucose of the blood, the blood of lipid cut down,the nerve conduction of speed was understandly improved,the rheology of the blood improved significantly alter the Neuropathy scores in DPN patients has been obviously depressed,the quality of life of sufferers has been reamarkeably improved,safety and small safe side in effectys,and furnish a determinate reference worth for the practitioner of Chinese medicine for the remedy of DPN.