The Associated Research Of Glucagon-like Peptide-1 And Metabolic Components

Purpose:Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has a wide range of effects on glucose metabolism and cardiovascular function (e.g., improving insulin sensitivity, reduction in appetite, modulation of heart rate, blood pressure and myocardial contractility, resisting ischemic and reperfusion). Metabolic syndrome (MetS) is associated with an increased risk of developing atherosclerotic cardiovascular diseases. Novel glycemic control drugs, the dipeptidyl-peptidase-4 (DPP-4) inhibitors, work by inhibiting the inactivation of incretin hormones, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP). In spite of good effects of these drugs in diabetic patients, circulating levels of incretins and their role in MetS are largely unknown.Methods:we measured circulating levels of incretins,TG,TC,HDL,LDL,UA,fasting insuline,fasting blood sugur,HbAlC,hsCRP and BNP in 112 obese high-risk patients for cardiovascular disease. According to metabolize index, the patients were divided into two subject groups:with MetS (n= 62) and contrast (n= 50).Results:All the clinical index including ages, weight, WC, BMI, fasting blood sugur, TG, U A, hsCRP and the rate of cornery disease about patient with MetS is higher then paitients with MetS of high risk, the difference exist after statistics analysis. Fasting levels of Serum GLP-1 of paitients with MetS (7.82+1.6μg/L) is higher then paitients with constrast (6.02±1.2μg/L). And this difference exist after sex and age being adjusted (P<0.01).Male(7.1±0.50μg/L) and female (7.3±0.58μg/L) have no difference (P> 0.05).According to different metabolic cent to set group.the levels of GLP-1 of each group rise as its metabolic cent. According to blood sugur condition to set group,normol group of blood sugur and abnormal group of blood sugur haven't distinct diffence about GLP-1 (P>0.05).Fasting levels of Serum GLP-1 have close relationship with MetS risk factors components (r=0.52.P<0.005). The levels of GLP-1 have also close relationship with hsCRP.There was also a significant interaction between GLP-1 and serum high-density lipoprotein cholesterol, triglyceride, and serum uric acid concentrations but not with waist circumference, fasting glucose, HbAlc, or presence of diabetes. Conclusion:fasting serum levels of GLP-1 have nearly relationship with MetS. MetS patients with elevated levels of GLP-1 are high-risk patients for cardiovascular disease, independent with the presence of diabetes.GLP-1 will be a new predictors for cardiovascular disease. Our research can also provide new pathology mechanism for nutrition overplus and Metabolic syndrome.but it also need more basic and clinical research to verifiy.