The Association Between Dynamic Changes Of Metabolic Syndrome And Type 2 Diabetes Mellitus (T2DM) Or Cardiovascular Disease (CVD)

Objective: to investigate the influence of dynamic changes in numbes of metabolic syndrome components for incidence of type 2 diaberes mellitus and cardiovascular disease during follow-up. Analyze and compare the role of alteration in each metabolic syndrome component played in incidence of type 2 diaberes mellitus and cardiovascular disease.Methord: Participants (male 1406, female 2055) were recruited from the Prevention of multiple metabolic disorders and MS in JiangSu province. Subjects with diabetes and CVD at baseline and first follow-up were exclude in our study. Difference of number of metabolic syndrome component was calculate by component number at follow-up minus which at baseline. The COX regression were conducted to compare the relative risk for T2DM and CVD of dynamic changes of metabolic syndrome.Results:1,Incidence of T2DM and CVD increased with the number of metabolic syndrome component increased; After adjusted for baseline age,sex and other risk factors, the aRR and 95%CI of incidence T2DM for subjects with metabolic syndrome compared to subjects who were not meet the definition of metabolic syndrome was 2.36(1.65~3.39) , and aRR for incidence CVD were 2.48(1.58~3.89).2,In both non-MS and MS group at baseline, the relationship of MS component and T2DM was obvious than that of CVD in both univariate analysis and multivariable analysis.3,In both non-MS and MS group at baseline, there were a positive correlation between the difference of number of metabolic syndrome component and T2DM, and the aRR were 1.45(1.14~1.86)and 1.53(1.16~2.03)respectively. Among the five MS components, changes in level of fasting plasma glucose play the greatest role in incidence of T2DM.4,In both non-MS and MS group at baseline,the correlation between the difference of number of metabolic syndrome component and CVD was weaker than T2DM. After adjusted for age and sex, the correlation was faded away. Only changes in level of blood pressure had an influence on incidence of CVD.Conclusion:1,In the group with MS at baseline, the risk for incidence of T2DM can decline if subjects turned into non-MS during follow-up; In contrast, the risk for incidence of T2DM can increase if subjects were exacerbation in MS during follow-up.2,In the group with non-MS at baseline, the risk for incidence of T2DM can increase if subjects turned into MS during follow-up, and the risk for incidence of T2DM was minimum if subjects were still without MS.3,We have not yet found the dynamic changes of MS had an influence on incidence of CVD , which may require more long-term observation study confirmed.