Association Study Among MRI, Pathology And Clinical Stages Of The Cervical Spondylotic Myelopathy

Objective:To study the characteristics of MRI and pathological change of cervical degenerative diseases,and analysis the correlation among MRI,pathological changes and clinical stages of cervical spondylotic myelopathy.Methods:Analysis the preoperative T2 weighted signal of MRI of 30 diseased disc from 23 cases of cervical spondylotic myelopathy patients under surgical treatment,and measure the relative signal intensity of diseased disc.With Pfirrmann grading system diseased disc divided into mild, moderate,and severe degeneration,HE staining was carried out to observe pathological changes and evaluate the degeneration degree,then analysis two kinds of evaluation methods and analysis their consistency.The data of moderate and severe degeneration from relative signal intensity assessment and histopathological examination evaluation were made analyzed and compared.At the same time the selected cases were devided into clinical stages with characteristics of MRI and pathological change,and compared clinical stages with MRI characteristics Results:Pfirrmann grading and the relatie signal grading system compared with histopathological grading system, Kappa values were 0.613,0.742 respectively.and there was high consistency;Coincidence rate between Pfirrmann grading and clinical stage was 69.6%; The data of moderate and severe degeneration from relative signal strength assessment was compared, t=4.314,P< 0.05,and there was statistical significance;The average number of live chondroid cells moderate and severe degeneration from relative signal strength assessment was compared, t=3.527,P< 0.05,and there was statistical significance. Conclusion:The MRI performance of the different degrees of cervical disc degeneration can reflect pathological changes,There was a certain corresponding relation between levelⅡ～V of MRI and Pfirrmann grading system with period 1～4 of the clinical stages;The relative signal intensity grading system could evaluation disc degeneration degree more objectively, the MRI assessment provide reliable imaging basis for the clinical stages of CSM.