| Objectives This study to ischemic stroke patients with Hhcy intervene, aimed at assessing different time after stroke patients with depression and plasma after stroke Hcy level relations, so as to understand the lowering of plasma Hcy level are beneficial to ischemic stroke patients after stroke depression improved.Methods1.Adopt forward-looking and parallel controlled trials method of open in August 2006-2007 October period from tianjin of hospital of the 3rd center nerve medicine hospital or clinic of this new hair more than 1 week (course) cerebral infarction 1,000 patients for 2 years of observation.2.1000 cases of patients with cerebral infarction Hhcy according to age, gender and affecting stroke risk factors of matching into interention group (treatment group, and group T) and the control group (control group, the group C), each group every 500 cases. Intervention group in patients with secondary prevention based on conventional add a composite B vitamins. The control group only used except B vitamins outside the routine therapy, two groups of patients with parallel regular follow-up.3.Record patients into group, intervention after 3 months,12 and 24 months fasting plasma tHcy level and in patients into group, intervention after 1/2 months,3 months, 6 months,12 months,18 months and twenty-four months respectively by means HAMD score evaluation of depression after stroke occur, depression in decline. HAMD> 7 points for may have depression cases, HAMD> 24 points cases of severe depression in.Results1.Intervention ergometry baseline plasma tHcy level, difference was statistically significant (p> 0.05).2.Composite B vitamins intervention after 3 months, the intervention group plasma tHcy, compared with controls difference was statistically significant (p< 0.05). Intervention to 24 months, intervention group plasma levels for tHcy, compared with controls difference was statistically significant (p< 0.05). 3.Two groups at baseline HAMD score intervention group and measured group no statistically significant difference (p> 0.05).4.Follow-up 1/2 months,3 months and 6 months intervention ergometry HAMD score difference between the two groups were not statistically significant (p> 0.05). Follow-up of 12 months,18 months,24 months, intervention group HAMD score below the control group, the difference between the two groups was statistically significant (p< 0.05). Patients were followed up for the whole of intervention group appeared in the incidence of HAMD> 7 points, the difference between the two groups was statistically significant (p> 0.05). Intervention group patients were followed up for 24 months and the incidence of HAMD> 7 points, comparative differences between the two groups was statistically significant (p> 0.05). Follow-up of 6 months intervention group new hair HAMD> 7 points cases, the difference between the two groups have statistically significant (p< 0.05). Over the follow-up time point difference between the two groups were not statistically significant (p> 0.05). Follow-up of 3 months,12 months,18 months intervention group HAMD> 7 points cases occur lower than those of the control group, compared between the two groups was statistically significant difference (p< 0.05). The remaining follow-up time point two groups HAMD> 7 points cases occur between groups comparative differences are not statistically significant (p> 0.05). Follow-up of 3 months intervention group severe depression cases (HAMD=24score) incidence, than in control group, comparative differences between the two groups was statistically significant (p< 0.05). The remaining follow-up time point two groups of severe depression cases (HAMD=24score) the incidence of comparative differences between groups were not statistically significant (p> 0.05).Conclusions Composite B vitamins intervention after 3 months, the intervention group tHcy level is relatively baseline plasma dropped, compared with controls, the difference was statistically significant intervention 12 to 24 months, intervention group plasma tHcy level has further decline. Clew to Hhcy of patients with cerebral apoplexy composite B vitamins intervention, in 3 months after drug can significantly reduced plasma tHcy levels and composite B vitamins within two years, can continue to effectively control plasma tHcy level. Patients with depression after stroke HAMD score index, follow-up of 12-24 months, intervention group HAMD score below the control group, the difference between the two groups was statistically significant. Follow-up the whole and the time of the latest follow-up HAMD> 7 patients,it difference were compared between the two groups was statistically significant. Clew composite B vitamins intervention in effectively reduce the Hhcy in patients with cerebral apoplexy plasma tHcy level of basic, may help to alleviate after stroke 1 to 2 years, but levels of depression on depression occurs and without influence. |
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