Salidroside Synthesis

Rhodiola sachalinensis is a perennial herb or the Asian bush plant of Rhodiola L.of Crassulaceae.Its,the stem,the flower,the seed all may be used as medicine, anti-virus,anti-tumor,anti-radiation,anti-senile,the immunity enhancement and so on.And it is called,continuing the ginseng and Ciwujia,the new generation of environment medicine to adapt the original.At present,it is obtaining the extensive research and application.The chemical composition in its original plant raw material for medicine mainly includes the glucoside class,the flavanone class,the coumarin,the tanning substance and so on,in which salidroside and p-tyrosol,while whose content is actually low,are its main active constituents.Therefore,it is necessary to carry on the separation and the depuration to its main effective components in order to overcome the shortcomings of badly product quality and the dosage in a big way in taking.The literature reported the separation and depuration methods include solvent extracting and column chromatography.The column chromatography may obtain salidroside of high-purity.However,with the seriously loss of effective component and the very low recovery rate,this method is only suited to apply to trace standard preparation. In this paper, synthesis of and itsanalog were p~pared from 2一(4-hydroxypheny1)一acetic acid byacylation,red uction,glu cosidation and alcoholysis The total yields were 80% to 85% .The above findings, further used for Rhodiola sachalinensis have provided the scientific basis, built the solid foundation for its new medicine development.