Obese Type Infarction And Toast Study

Objective:Obesity is a risk factor for ischemic stroke. Obesity according to different standards are divided into various types. The relationships between the ischemic stroke and obesity subtypes are seldom known. This study was to investigate the relationships between the usual ischemic stroke etiologic subtypes and obesity subtypes and further mechanism. Methods:304 patients of ischemic stroke were divided into large artery atherothrombosis (LAA),small artery disease (SAD), stroke of undetermined etiology (SUD), cardioembolism (CE) and stroke of other determined etiology(SOD).Gender and age were matched in control group and 282 healthy individuals were measured waist circumference and height and weight to calculate body mass index (BMI). All individuals were devided into abdominal obesity (AOB) and non-abdominal obesity (non-AOB) by waist circumference as a parameter and into normal, overweight and obesity by BMI. Hypertension, diabetes, hyperlipidemia were met the appropriate standards for the diagnosis. On admission.Blood pressure was tested.Fasting blood parameters:blood glucose, triglycerides, cholesterol, LDL, HDL, creatinine, uric acid were tested in 24 hours. Univariate analysis:chi-square tested count data and t test or analysis of variance tested measurement data; the significant variables of univariate analysis and common histories were tested by the multi-factor Logistic regression analysis Result:High systolic blood pressure, high fasting blood glucose, older than 65 years of age, high LDL, diabetes mellitus, history of hypertension, history of high blood fat were independent risk factors for ischemic stroke. High triglyceride, high cholesterol, high uric acid were negative with ischemic stroke. The types of obesity were not correlated with ischemic stroke. Stratification of gender and age showed that in overweight or obese group of BMI in GOB, men over 65 years old in ischemic group were more than control group and women of diffient types of obesity in different age groups had no statistically significant differences between ischemic and control group.In patients of ischemic stroke between AOB and N-AOB, the proportion of abdominal obesity among men was lower, and history of diabetes, fasting blood glucose, cholesterol, triglyceride, cholesterol and uric acid in AOB was higher than N-AOB with statistically significant differences. In patients of ischemic stroke among normal,overweight and obese groups classified by BMI, history of diabetes had statistically significant difference between obese and normal group, triglyceride levels in obese and overweight was higher than normal group with statistical significance and uric acid level in overweight and obese group than normal group, with statistical significance. Proportion of TOAST subtypes in various types of obesity had no statistically significant difference. Conclusion The preliminary results suggest that types of obesity are not related with ischemic stroke and the elderly men of overweight or obese are associated with ischemic stroke. There are no relationships between obesity subtypes and TOAST subtypes and the mechanism of vascular impairment correlated with the obesity needs further study.