The Relationship Between Serum SAA, Hs-CRP And TOAST Subtypes In Patients With Ischemic Stroke

Objective:To investigate the changes of the serum amyloid A protein and high sensitivity C-reactive protein level in patients with ischemic stroke, and the relationship between the serum amyloid A protein and high sensitivity C-reactive protein level and subtypes by The Trial of Org10172 in Acute Stroke Treatnent(TOAST).Mothods:A retrospective case-control study was used, and the data was prospectively collected from 262 consecutive ischemic stroke inpatients in our department from November 2012 to January 2014. The cases of control group were healthy people at the period time. They were classified into 5 subtypes shown as follows, 1arge-artery atherosclerosis(LAA group),small-artery occlusion(SAO group), cardio-embolism(CE group), stroke of other demonstrated etiology(SOE group), and stroke of undemonstrated etiology(SUE group), The serum levels of SAA were measured by ELISA.The serum levels of CRP were measured by immunonephelometric assay.Results:The percentage of each ischemic stroke TOAST subtypes of 262 patients was as following: stroke of largeartery atherosclerosis 28.63%, cardioembolism 11.83%, small-vessel occlusion 47.71%, other determined etiology 8.40% and stroke of undetermined etiology 3.43%. The serum SAA, hs-CRP levels of patients were significant higher than those of controls(p<0.05). The levels of serum SAA, hs-CRP in CE group was the highest, the higher group was LAA, group of SAO was the lowest. The serum levels of hs-CRP were positively correlated with that of SAA in ischemic stroke(r=0.812,p<0.001).Conclusions:SAA and hs-CRP level varied with difference subtypes of ischemic stroke. The SAA and hs-CRP may play a role in ischemic stroke development. The elevation of serum SAA and hs-CRP could be a potential indicator of disease aggravation.