Model Of Gastric Electrical Activity And Gastric Slow Wave And Peristaltic Wave Three-dimensional Simulation,

Gastric electro-mechanical activity (GEMA) is foundation to complete its normal functions. Although it has been many results by studying, modeling and simulating for many years, there is still no relevant reports of quantitative relationship and three-dimensional dynamic simulation .The main work of this thesis is to analyze the model of gastric electrical activity (GEA), to establish its propagation model and peristalsis model in three-dimension, and then, to simulate it in dynamic three-dimension.Based on the description of GEA and GEMA about its generation, characteristics and functions, this paper analyzes and simulates ion-mechanism model, summarizes the characteristics and laws of different cells at first. Secondly, it studies the propagation models about the GEA. Finally it models the electro-mechanical relationship and its propagation, and then succeeds in three-dimensional dynamic simulation. The thesis paid more attention to the model-building of three-dimensional stomach which is approximated to its true shape, and of GEMA, as well their simulations by Matlab.This paper analyzes the traditional ion-mechanism models which are H-H and FHN models by Matlab. We use the images to show the laws of electrical activity about the different type cells. It makes a better understand of the difference between pacemaker cells and smooth muscle cells as well as their roles. It also proves that these models are reasonable.This paper studies the cone and column propagation model of GEA, and analyzes the laws of it, models and simulates the propagation of slow-wave by model-building methods and principles using Matlab. The results reveal its propagation law and confirm the reliability of conduction models.It is the first to realize the modeling and simulating the three-dimensional complex stomach that is close to its true shape using Matlab. In order to approximate to the true shape, this paper uses a number of deformed cones (or columns) to combine for simulating the static stomach, it gets a static three-dimensional model of the stomach. It describes the modeling methods and principles in detail, gives the corresponding program and simulative results.Based on its laws, it is the first to establish a model of the quantitative relationship of GEA and peristaltic contraction, and a three-dimensional dynamic model of its propagation. It is the first to achieve three-dimensional dynamic simulation successfully using Matlab. According to the actual gastric physiology and the established model , it establishes quantitative relationship model between GEA and peristalsis, and further establishes a propagation model of GEMA by conduction laws.Finally,it simulates the propagation of GEA for the resting gastric and of GEMA for peristalsis gastric separately in dynamic three-dimension.It gives the corresponding simulated results.By modeling and simulating, it vividly demonstrates the spreading process of GEA and gastric peristalsis contraction, and provides some simulative methods and cognitive means for GEMA.In a word, our study has not only enhanced understands to electrophysiology and gastric motility, but also vividly showed the spread of GEA and mechanical activity as well as the relationship of them. In particular, it has provided new study and cognize approach for precise quantitative relationship between GEA and gastric motility, which can have it play a greater role in diagnosis and studies for gastric diseases.