| Nerve fiber electricity activity regulates human body’s enginery. In clinic, abnormal nerve fiber activation can cause many disorder diseases. Block nerve conduction by researching nerve fibers conduction can restore the normal function of some damaged nerve. Therefore, the study for unmyelinated nerve action potential propagates and conduction block with electrical stimulation have attracted wide attentions for clinical applications. Based on a large number of nerve fiber’s study from different researchers, mathematical models were set up to simulate the block nerve conduction with electrical provoke (not sure which character should be used). Some complex biological mechanisms of nerve fiber were also revolved. The research with nerve model has become the most effective method of for studying potential changes in nerve fiber.Based on Hodgkin-Huxley (H-H) model, taking the unmyelinated nerve fiber as the research object, unmyelinated nerve fiber block threshold, influences and blocking mechanisms were studied under high frequency biphasic electrical stimulation. A measurement method for finish electrical stimulation and the time of axon recovery the initial state was also studied. The main works of this paper are as follows:1) Unmyelinated nerve conduction block model was made based on H-H model, nerve fibers’block threshold of nerve fiber with different diameter by high frequency biphasic electrical stimulation was found, and the minimum block frequency was determined;2) Through studying the blocking mechanism of unmyelinated nerve model, influences of block threshold by temperature and electrode distance-nerve fibers were figured out;3) Comprehensive investigation the beginning and end of the electrical stimulation of nerve fibers’ state;4) After the electrical stimulation, novel research for nerve fiber to restore the initial state was conducted. Recovery time of nerve fiber with different diameter and the mechanism of ion channels and Na+/K+pump were determined. |
