Coronary Heart Disease Syndromes Change With Changes In Lipid Profile

Objective:This study was designed to investigate the Traditional Chinese medicine (TCM) syndromes distributions and the lipid spectral distribution of the coronary heart disease (CHD) patients with the epidemiological method supported by the National 973 plan grant, "the systematic research of etiology between cardiovascular thrombotic disease and the stasis and toxins (a concept of TCM theory)", and explore the correlation between the TCM syndromes and the lipid spectral distribution for establishing the sufficient basis of the disease prevention and cure and the differential treatment in TCM in future.Method:We selected randomly 533 cases with CHD (male 374, female 159, mean age 62.27±8.71years) discharged in Anzhen Hospital, all of them were consistent with the including and excluding standards,278 cases of them are completed the period of 6-month follow-up and 101 cases of them are completed the period of 12-month follow-up.We packed the patients into 3 groups according to the patient follow-up time,the follow-up group,the 6-month follow-up group and the 12-month follow-up group. This study recorded demographic data, medical history, symptom, Medication compliance, etc. for all patients. Upper limb venous blood when in empty stomach condition was collected on the follow-up day. The blood Lipid was tested by the laboratory of Anzhen Hospital. Total cholesterol(TC) was tested by CHOD-PAP and Triglyceride(TG) was tested by GPO-PAP. High density lipoprotein cholesterol(HDL-C) was tested by PTA-Mg2+. Low density lipoprotein cholesterol(LDL-C) was tested by PVS. The patient message was input into the database. SPSS17.0 software was used to clean and analyze the statistic. We use frequency statistics analysis for General information, mean±sd for measurement data and a chi-square test for counting material.Result:1.50 to 79 years of age is the main Age distribution of CHD patients and there is a significant difference between male and female (P< 0.05).2. The TCM syndrome distribution extent of follow-up group is as follow:phlegm syndrome> Qi Deficiency syndrome>Blood stasis syndrome> Yin deficiency syndrome> Yang Deficiency syndrome> Qi stagnation syndrome> Cold Coagulation card syndrome. The TCM syndrome distribution extent of 6-month follow-up group is as follow:Blood stasis syndrome>phlegm syndrome> Qi Deficiency syndrome> Yin deficiency syndrome> Yang Deficiency syndrome> Qi stagnation syndrome > Cold Coagulation card syndrome. The TCM syndrome distribution extent of 12-month follow-up group is as follow:Blood stasis syndrome> phlegm syndrome> Qi Deficiency syndrome> Yin deficiency syndrome> Yang Deficiency syndrome> Qi stagnation syndrome> Cold Coagulation card syndrome.3. Blood stasis rates have significant difference in the follow-up with 3 times,(p< 0.01). Yin deficiency syndrome rates have obvious differences between the 6-months follow-up group and follow-up group (p< 0.05).The rest syndrome have no significant differences (p> 0.05).4.The Normal rate in Lipid profile of follow-up group is as follow:TC(71.11%)> LDL-C (69.79%)> TG(51.78%)> HDL-C(42.03%); The Normal rate in Lipid profile of 6-month follow-up group is as follow:LDL-C (56.83%)> TC(52.52%)> TG(38.49%)> HDL-C(37.77%); The Normal rate in Lipid profile of 12-month follow-up group is as follow:LDL-C (64.36%)> TC(59.40%)> HDL-C(56.44%)> TG(44.55%).5.HDL-C abnormal rates have significant differences in three times follow-up (p<0.01); TC,TG and LDL-C abnormal rates have no significant differences in three times follow-up (p > 0.05).6. The rate of phlegm syndrome and Qi Deficiency syndrome are more than it of the rest of syndrome in Low HDL-C patients (P<0.05). The rate of Blood stasis syndrome is more than it of the rest of syndrome in High LDL-C patients (P<0.05). There have no significant differences in the Correlation between TC,TG and the TCM syndrome (p> 0.05).Conclusion:1 CHD is common in elder people,male is lower than female in age of onset. age of onset of females were more concentrated in the postmenopausal age.2 Phlegm syndrome, Qi Deficiency syndrome and Blood stasis syndrome play important roles in CHD,they run through the course of coronary heart disease and they are the main pathogenesis of coronary heart disease.3 Blood stasis is the main risk factors for coronary artery disease, and the blood stasis syndrome rate is increasing with the progression of CHD.The result of that Yin deficiency syndrome rates have obvious differences between the 6-months follow-up group and follow-up group is prove that there still have remaining evil in body althoug exogenous pathogens have been cured.4 LDL-C level is best controlled in lipid profile in CHD.Maybe it is because that most of the patients use the Statins to control the lipid, stable plaque for long-term.5 HDL-C abnormal rate in patients were increasing after they discharged,it was because of the poor drug compliance and bad habits such as smoking,drinking and eat more fat.6 In TCM syndrome, phlegm, blood stasis and Qi deficiency have the most close relationship with lipid profile in CHD. Blood stasis syndrome is closely related to high LDL-C in CHD and it is suggest that the changes of LDL-C in coronary heart disease patients can be considered as a reference indicator of blood stasis syndrome.