| Objective:This clinical study investigated cognitive function in people with hypertension, high sensitivity C-reactive protein (Hs-CRP) and TCM syndrome of cognitive impairment and vascular endothelial damage index of high sensitivity C-reactive protein (Hs-CRP) and between TCM syndrome relations, to further explore the pathogenesis of hypertension in cognitive impairment, in order to obtain Integrative Medicine Clinical Diagnosis of vascular cognitive impairment are instructive conclusions.Methods:A cross-sectional survey method, select the 127 cases of hypertensive patients, the application of information scale TCM four diagnostic symptoms and syndromes of Chinese medicine practitioners investigation.Compiled by the Chinese Academy of Sciences Institute of Psychology of Memory Scale (Clinical memory scale, CMS) A package used to assess memory function, interference-term test (STROOP TEST), breadth of digital memory test (DS),painted bell Experiment (clock drawing test CDT), connected with the overall assessment of cognitive function. Diagnosis of hypertension refers to 2007 China Hypertension Prevention Guide diagnostic criteria. The biochemical laboratory disciplines latex enhancing immune turbidity measure Hs-CRP levels.Results:1 Forgetfulness, dry mouth, head and dazed frequency above 80%, they could be owned by the core symptoms of this study. On the frequency of occurrence of 50% or more of the symptoms of cluster analysis, the reference to the relevant literature and teacher experience, clustering analysis, a comprehensive analysis of the results, concluded that cognitive impairment in high-risk groups a common card types. In this study of cognitive dysfunction in high-risk groups commonly followed by Shenxu, Tanhuo, Tanzhuo, Qixuxueyu, Qixuekuixu.2 By Spearman, high-sensitivity C-reactive protein and the frequency of Shenxu there is a very significant positive correlation (P<0.01),by chi-square test, Tanzhuo, Qixuxueyu frequency of deficiency in high-sensitivity C-reactive protein in normal and abnormal group difference was extremely significant.3 Shenxu and physical knowledge, writing ability, Clock Drawing test, point to memory, age, total score by the correlation was significant (P<0.05), and the execution, associative learning, there is a very experimental Total Connection significant correlation (P<0.01);Tanhuo and point to significant correlation (P<0.05); Tanzhuo and reading ability, clock drawing test, associative learning, there was significant correlation (P＜0.05); Qixuxueyu and execution, graphics significant correlation (p<0.05);Qixuekuixu and the execution, associative learning, there was significant correlation (P＜0.05).4 The t test, Shenxu between the groups with and without time orientation, spatial orientation, physical awareness, writing ability, digit span, STROOP TEST1, point to memory, associative learning were significantly different (P＜0.05), and MQ had significant differences (P＜0.01); Tanhuo between groups with and without memory were significantly different (P<0.05); Tanzhuo between groups with and without reading ability, clock drawing test, associative learning, MQ were significantly different (P<0.05); Qixuxueyu between the groups with and without executive power, graphics capabilities were significantly different (P＜0.05);Qixuekuixu with and without executive power between groups, associative learning, there are significant differences (P＜0.05).5 The t test, the Shenxu/Tanhuo between groups with or without physical awareness, image free recall were significantly different (P＜0.05), and the language repeat, execution, writing ability had significant difference (P＜0.01); Shenxu/Tanzhuo between the groups with or without combination of associative learning were significantly different (P＜0.05), and time orientation, spatial orientation, physical cognitive, language repetition, executive ability, reading ability, writing skills, drawing ability, STROOP TEST1 had significant differences (P＜0.01); in Tanhuo/ Tanzhuo combination of syndromes with or without evidence of reading ability between the groups were significantly different (P<0.05),And immediate memory, executive ability, drawing skills had significant differences (P＜0.01); in Shenxu /Tanhuo/Tanzhuo portfolio syndrome between groups with or without time orientation, immediate memory, MQ were significantly different (P＜0.05), and spatial orientation, the physical existence of significant differences in cognition (P＜0.01).6 Hypertension's hs-crp and digit span, STROOP TEST2, MQ between the correlation was significant (P＜0.05), and image free recall had significant correlation (P＜0.01). In HsCRP normal and abnormal groups were compared, calculating ability, language repetition, reading ability, image free recall were significantly different (P＜0.05), total score of age, MQ, STROOP TEST1 There were significant differences (P＜0.01).7 The t test, with or without hyperlipidemia between the two groups, cognitive testing in transient memory, writing ability, drawing skills were significantly different (P＜0.05), STROOP TEST1 had significant differences (P＜0.01). In Hyperlipidemia abnormal hs-crp in both group and non-merger between the two groups, cognitive testing in transient memory, MQ, STROOP TEST 2 were significantly different (P＜0.05), space orientation, execution, age, total score, STROOP TEST 1 had significant differences (P＜0.01).Conclusion:The study found that forgetfulness, dry mouth, head and dazed is the highest frequency of symptoms, high blood pressure groups for the core symptoms of cognitivedysfunction. This study used clustering methods in the literature and instructors of the experience of cognitive impairment among people with hypertension were studied divided Syndrome and found that Shenxu, Tanhuo, Tanzhuo, Qixuxueyu, Qixuekuixu is a common cognitive dysfunction syndrome types. TCM such as:Shenxu, Tanhuo card, Tanzhuo and vascular endothelial injury markers HsCRP there is a link, but also cognitive impairment associated with these syndromes. This study also used serum HsCRP levels on cognitive function and essence of TCM Syndromes made preliminary microscopic study, found that the level of abnormal Hs-CRP decline of cognitive function with a certain relationship exists between; Shenxu,Tanzhuo,QixuxueyuHs-CRP higher levels of hypertension,brain inflammation is more important, lower cognitive function scores. It showed true, Xu, Tan,Yu, Huopathogenic factor in the development of cognitive impairment may play an important role, might be the cause of cognitive impairment, suggesting that "poison" evil generation, may be dirty cloud, such as:Xu, Tan,Yu, Huo and other pathological findings from the quantitative to qualitative changes,The " damaged brain Toxinluo " is the key to the development of exacerbations. |
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