| Objective1. Observating the clinical efficacy of disease treatment for Winter Disease Point Application therapy of adult bronchial asthma.2. Observating the Winter Disease Point Application therapy of bronchial asthma causing the degree of skin reaction conditions. To improve efficacy and the efficacy of high-quality evaluation and lay the foundation for basic research.3.Refer to topical skin irritation, to establishment a new evaluation and the degree of clinical efficacy studies for Winter Disease Point Application therapy of skin reactions caused by the strong correlation.MethodWith the method of prospective cohort study,according to inclusion criteria included cases of clinical information collected on a regular basis,to Point Application out patients in Dog Days in Department of Respiratory in Dongzhimen Hospital, selects the 500 cases of herbal plaster in respiratory outpatient of asthma for two-year. After herbal plaster, group the degree of skin response into different research groups to observe the different reactions of the skin treatment groups and the degree of skin reaction and their relevance in the dog days for two years. Based on the observations and draw up a unified form, fill in the form of the elements before and after treatment, finally statistical analysis and draw conclusions.ResultsAccording to the clinical research program collected a total of 400 patients,divided into four groups under the external application presence or absence of skin reaction and the reaction estent, that is, no response of skin, abnormal skin reaction group (including flushing, itching, burning sensation, tingling and other relatively light performance etc.), skin blister group (including small blisters, blisters and other great performance etc.), skin allergy group (including skin infections, or on tape, sticking drug allergy, etc., showed local irritation unbearable itching burning around congestion swelling, peeling, or even erosion, exudation, multiple papules, ulcers, etc.). With changes of the disease extent and frequency of attacks in comparison group, groups differences of no response, abnormal response group, blisters group, allergic group before and after treatment were statistically significant (P<0.05). After treatment, the disease extent and frequency of attacks was significantly lower than before treatment; to the extent of the changes of the disease, the skin blisters on the skin group was better than no response group; skin allergy group was better than skin no reaction group (P <0.05); other groups were not significantly different (P> 0.05); to the change of the frequency of qttacks, skin blisters group was better than no response group and skin abnormal response group (P<0.05), other groups were not significantly different (P> 0.05). Four groups of self-evaluation on the applicator rather satisfactory, all above 80%, group self-evaluation in patients with no significant difference in satisfaction (P> 0.05).ConclusionThrough statistical analysis, Drug Acupoint Application of bronchial asthma have significant efficacy, but a strong local skin reactions in patients with the clinical efficacy was better than no any skin reactions or general reaction group, that is Point Application of treatment with whether local skin reactions or not and the degree of local skin response have a positive correlation. Patient self-assessment of the applicator more than 80% satisfaction rate. |
