Chronic Obstructive Pulmonary Disease In Patients With Pathogens

Objective: To analyze respiratory tract infections and drug resistance of pathogenic bacteria classification with the chronic obstructive pulmonary disease (COPD) patients, to provide a favorable clinical basis for rational drug use.Methods: From January 2008 to 2009 January Third Xiangya Hospital, Central South University 563 cases diagnosed as COPD patients discharged from hospital were retrospectively analyzed sputum samples for sputum culture and sensitivity test, the results for analysis.Results: There were 205 (36.41%) cases of positive meeting in 563 cases of patients' .Non-Pulmonary heart disease group positive results at 85 (15.10%) cases, pulmonary heart disease group result at 120 (21.31%) cases. Positive test results of 205 cases of G+ bacteria were detected 46 (22.44%) cases of times, G- bacteria times 119 (58.05%) cases, fungal times 40 (19.51%) cases. Patients with CAP were much more than HAP (P <0.01); Most of the G + bacteria infection were Staphylococcus aurous (14 cases), followed by Staphylococcus epidermidis and Streptococcus viridians; Most of the G-bacteria infection were Pseudomonas (37 cases), followed by Klebsiella. Pulmonary heart disease group was significantly higher than that of non-pulmonary heart disease group (P <0.01) in the infection of Pseudomonas; fungal infection of Candida albicans to a maximum of I-type (20 cases), followed by Candida albicans II. Staphylococcus aurous resistant to multiple antibiotics, to penicillin and ampicillin, resistance rate of up to 100% to the azithromycin, cefazolin, erythromycin and cotrimoxazole resistance in the high rate of oxacillin, ceftazidime , levofloxacin, moderately sensitive to Vancomycin , imipenem sensitive; Pseudomonas aeruginosa sensitivity test suggests that for ampicillin, piperacillin, cefazolin, cotrimoxazole resistance seriously, to imipenem, includingβ-lactamase inhibitor, co-agents more sensitive, drug sensitivity test Klebsiella tips to piperacillin and cefazolin-resistant serious drugs, to imipenem, includingβ-lactamase inhibitors, quinolones joint preparation and more sensitive. Fungal drug sensitivity test showed that: accounting for 50.81% of fluconazole-sensitive, accounting for 30.12% of Itraconazole- sensitive, accounting for 30.83% of the ketoconazole-sensitive accounting for 10.74% of 5-fluorocytosine- sensitive. Invasive operation group was higher than non-invasive operation in bacteria infection (P <0.01).Conclusion: Pulmonary heart disease group with infection Pseudomonas aeruginosa resistance to antibiotics was significantly higher than group without pulmonary heart disease combined ; Invasive operations increase opportunities for secondary fungal infections.