| Objective:1 through the detection of acute severe head injury patients plasma endothelin content, to explore the mechanism of traumatic brain edema.2 observation Danshen treatment of acute severe head injury and to explore the clinical effects of the mechanism of its effect.Materials and methods:Acute severe brain injury 30 patients were randomly divided into control group and the test group. 15 cases of the two groups. Control group of conventional Western medicine treatment, the experimental group in the conventional therapy plus treatment of Danshen injection. Danshen injection 20 milliliters of 5% glucose injection 250 ml intravenous drip, 1 times / day. In the treatment of each patient before and after treatment for 24 hours, 48 hours, 72 hours, 1 week and 2 weeks, respectively, to take brachial vein method to non-equilibrium plasma endothelin (ET) content, testing the patient's blood pressure group. Two groups of patients in the treatment before and after treatment three days, 1 week trip Glasgow coma score (GCS), after treatment 72 hours a week lumbar puncture line detection of intracranial pressure, comparing the efficacy of the two groups.Results:1 patient in each group of plasma ET content1. 1 control group, the experimental group pre-treatment plasma endothelinlevels were increased significantly, with the normal reference value (50. 8±7. 58pg/ml), compared with statistical significance (P<0. 01) and control group,plasma endothelin reached a peak value of 48 hours;1.2 in control group, experimental group one week plasma endothelin contentover the previous 72 hours significantly decreased, compared with statisticalsignificance (P <0. 05), and two weeks when the two groups were close to normal; 1.3 Test group after treatment, plasma endothelin content signifycantly lower than the control group, compared with statistical significance (P <0.05); 1. 4 Endothelin test group within 48 hours in the treatment of consecutive decline, a slight rebound in 72 hours, after the marked decline again.2 patients in each group GCS scoreGCS score of control group and experimental group was signifycantly increased, compared with statistical significance (P <0. 05). And treatment 72 hours a week than the obvious change, compared with statistical significance (P <0. 05).3 test group of patients blood pressure measurementTest group after treatment, systolic pressure, diastolic pressure, respectively, compared with a slight decrease in pre-treatment, no statistical significance (P resumption> 0.217, P Shu> 0.199).4 patients with intracranial pressure were measuredLumbar pressure test group compared with the control group decreased significantly compared with statistical significance (P <0.05), and the treatment of one week Danshen group intracranial pressure near normal.Conclusion:1. Endothelin content in patients with traumatic brain edema is closely related mechanisms.2 endothelin control group 48 hours and reached the peak value, indicating that endothelin is involved in brain injury 48 hours before an important pathological process endogenous injury factor. Measurement of plasma endothelin can be used as evaluation of the extent of brain injury and treatment effect of one of the indicators.3 experimental group and control group of drugs to reduce plasma endothelin levels were effective. Experimental group can signifycantly reduce the plasma endothelin concentration and delayed its peak time. 4 experimental group of patients can reduce intracranial pressure, improve the patient's GCS score, improving clinical symptoms. Danshen than a simple combination of western medicine group more effective.5 experimental group of patients blood pressure was not obvious.Danshen through effective suppression of the production and release of ET, reduce plasma ET levels, improve the microcirculation of the high viscosity state to reduce brain injury after cerebral edema and reduce intracranial pressure, thereby improveing clinical symptoms. Salvia can be seen on the severe brain injury with clinical treatment. |
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