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Protective Effect Of Compound Chinese Medicine Preparation Of Sports Rat Heart And Mechanism Study

Posted on:2010-06-23Degree:MasterType:Thesis
Country:ChinaCandidate:R ZhangFull Text:PDF
GTID:2204360275955326Subject:Human Movement Science
Abstract/Summary:
1 Objective:The main purpose of this paper is to observe the influence of the compound prescription of Chinese traditional antioxidial medicne on the enzyme activity or some contnet of the rats cardium and serum from different group rats,discuss the merchanism of the cardium antioxidial injury and how can the medicine to protect the cardium from injuring.In order to provide some scientific theory basis of training and explore some chinese medicine bavery for protecting the cardium from injuring.2 Method:120 female Wister rats were randomly selected and divieded into 4 groups:A(the peachful control group),B(the peathful group to fill medicine group),C(movement training group),D(movement training plus medicine group).The A,C group drink water freely every day,while the B,D group drink the chinese medicine bavery institute water.And,the C,D group LDst 8 weeks swimming train with a load about 3%of their own body on the tile:at the first week,the training time is 30 minutes every day;the second week,is 40 minutes...;like this the training time is 10 minutes more than the before week.So the training time is 100 minutes at the 8th week every day.After 8 weeks,divid each group into 5 subnits stochastically:the peachful group,the quota load 1 hour group,the strength using up group,the 12 hour recovery group after strength using up,the 24 hour recovery group after strength using up.The activity of the SOD,LDH,Ca2+-ATPase,Na+-K+-ATPase from cardium and the MDA,total Ca2+,LD content from cardium were measured.All data count uses the software with SPSS12.0 to carry on the T-test,the obviouse standard is P<0.05,the very obviouse standard is P<0.01.The software with Word 2003 to picture.3 Results:3.1 In quite stae,in the tissue of cardaic muscle,the MDA content of group C is very obviously lower than group A(P<0.01);group D is higher than the other groups.The activity of SOD in group B and C are both higher than group A(P<0.05);group D is very obviousyly higher than the other groups,P<0.01;the activity of Ca2+-ATPase in group C is higher then group A(P<0.05);group D is higher than group B and C(P<0.05).3.2 At the immediate ends of exhaustive exercise,in the tissue of cardaic muscle,the content of MDA in other three groups are very lower than group A obviously,(P<0.01);the activity of SOD in the group B and C are both higher than group A(P<0.05);and group D is very obviously higher than the other three groups,(P<0.01);the content of total Ca2+ in the other three groups are very obviously lower than group A(P<0.01);and group D is the lowest.the activity of Ca2+-ATPase in group B is obviously higher than group A(P<0.05);and group D is the lowest in the four groups.the content of LD in group D is obviously lower than group A(P<0.05).the activitity of LDH in group D is obviously higher than group A and C(P<0.05),also very obviously higher than group B(P<0.01)..3.3 In the quota load 1 hour conditon,in the tissue of cardaic muscle,the content of MDA in group D is lower than group A and B obviously;the activity of SOD in group C is very obviously higher than group A(P<0.01);group B is obviously higher than group A,(P<0.05);also,group D is the highest in the four groups;the cotent of total Ca2+ in group B and D is very obviously lower than group A(P<0.01);also,group A is lower than ther other two groups.the activity of Ca2+-ATPase in other three groups are higher than group A,P<0.05,and group D is the highest among the four groups.3.4 In the condition of 12 hour recovery after strength using up,in the tissue of cardaic muscle,the content of MDA in group D is obviously lower than group A,P(<0.05 );the activity of SOD in group B and D are both higher than group A,(P<0.05);also,group D is obviously higher than group B and C(P<0.05).the content of total Ca2+ in group B is very obviously lower than group A(P<0.01);group C is obviously lower than group A(P<0.05);and group D is very obviously lower than other three groups;the activity of Ca2+-ATPase in group B and D are both very obviously higher than group A(P<0.01);and group D is obviously higher than group C(P<0.05);the activity of Na+-K+-ATPase in group D is obviously higher than group A,P<0.05;however,group D is very obviously higher than group B and C(P<0.01);he content of LD in group D is obviously lower than group A,and very obviously lower than group B.the activity of group A is very obviously lower than the other three groups(P<0.01),but,there is no difference among the three groups..3.5 In the condition of 12 hour recovery after strength using up,in the tissue of cardaic muscle,the content of MDA in group D is very obviously lower than group A(P<0.01);the activity in the other three groups are very obviously higher than group A,(P<0.01);group D is also lower than group B and C;the content of total Ca2+ in the other three groups are very obviously higher than group A,(P<0.01);and group D is very obviously lower than group B and C(P<0.01);the activity of Ca2+-ATPase in group B is very obviously higher than group A, (P<0.01);group D is very obviously higher than group A and B,P<0.01;the activity of Na+-K+-ATPase in group D is obviously higher than both group A and B(P<0.05);also,group D is very obviously higher than group B(P<0.01). 4 conclusion4.1 The 8 weeks cyclical aerobic endurance swimming training may improves rats antioxidant capacity in myocardial tissue,To maintain the integrity of myocardial cell membrane;and play a important role in the progress of protectiing myocardial tissue.4.2 The antioxidant compound chinese medicine can clear the free radicals in rat myocardium, reduces lipid peroxidation,improves rat antioxidant capacity in myocardial tissue;there is conducive to the maintenance of myocardial cells within the environment of stability, effectively;so that,it inhibites the occurrence of calcium overload,protects the integrity of the cells;and play a postive in the recovery progress of myocardial injury after exercise.4.3 Aerobic endurance swimming training with the compound of the joint use of antioxidant compound chinese medicine is very positively from oxidative stress injury and to promote recovery after injury;of course the jiont use is more effective than simply a method.
Keywords/Search Tags:oxidative stress, cardium injury, swimming train, the compound Chinese medicine antioxidant, protection
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