Formulated With Cinnamon Blunt Pieces Of Pharmaceutical Research

Instant Rougui ultra-fine powder is a kind of medicine taking after mixed with water. Systematic studies on Rougui ultra-fine has been carried out according to the Powder and concentrated granule research mode under the guidance of Chinese Traditional Medicine and Pharmacy.Considering clinical demand and the volatility of naphtha in Rougui, the preparing procedure of Instant Rougui ultra-fine powder is developed and compared with both the mean particle size and the Dissolving quality used as the criteria. The optimized technology is: Comminute Rougui into coarse grain, dry coarse grain to low down the moisture content to 5%-7% at 50-60℃. Ultra-fine 4.8kg of coarse grain in SYFM-100 vibrating miller with a 70% stuffing rate, add Tween -80 192g, cane-sugar 576 g, Carboxymethyl Starch Sodium 384g after 30min, then collect product 10 more minutes later.The research is focused on measurement of particle size of product in the aspect of quality criteria, We established the methods of detecting particle size with Laser Scattering Particle Size Distribution Analyzer.The content of cinnamaldehyde is also studied with HPLC. By examining batches of samples, the mean particle size should be larger than 10μm and cinnamaldehyde content must not less than 12mg/g. Introduce Dissolving quality detemanition into the quality criteria to better control he quality of Instant Rougui ultra-fine powder .The stability test has been fulfilled according to the preliminary quality standard and related rules, which indicates that the packed granule was stable in 6 months. Results of acute toxicity indicate that Rougui powder and Instant Rougui ultra-fine powder have a large safety dose.All the experiments mentioned above prove that the preparing procedureis reasonable and practicable, the standard is controllable, and the finished product is safe and effective as well as stable.