| Objective: Through acupuncture method treatment experimental diabetes big rat, observes its blood sugar, the blood fats , heart than weight and Angiotonin II of muscle influence. It is the purpose of analyzing the acupuncture curative effect the mechanism, treats diabetes for the acupuncture the modern mechanism research to provide the basis.Methods: 1. Will conform to request male Wastar big rat 40, divides into 3 groups stochastically: blank group, model group, acupuncture group.2. Streptozotocin of 55mg/kg is injected abdominal cavity to manufacture diabetes big rat model.3. After makes the big rat model success, it is acupunctured every other day 1, each time 30min, continual acupuncture 12 weeks.4. The big rat abrosia 12h after achieved the treatment course first, then etherization and executes after picked the eyeball to draw blood , application convention biochemistry target examination blood sugar, blood fats. Open the chest cavity, select the heart fast, with the isotonia physiological saline clean, snip great vessels , to weigh after blotting blood for filter paper , manufacture even seriflux. Determining Ang II contents is determined by radio-immunity law to determine even seriflux.Result: 1. Impacting of acupuncture over diabetes big rat weight: there are a very significant difference each group than the control group at 14 weeks (P<0.01) , Acupuncture group compared with the model group were significantly different (P<0.05) .2. Impacting of acupuncture over diabetes big rat blood sugar: there are a very significant difference each group than the control group at 14 weeks (P<0.05) , Acupuncture group compared with the model group were significantly different (P<0.01) .3. Impacting of acupuncture over diabetes big rat of blood fat: about TG , there are a very significant difference each group than the control group (P<0.01) , Acupuncture group compared with the model group were significantly different (P<0.01) ; CH, there are a very significant difference each group than the control group (P<0.01) , Acupuncture group compared with the model group were significantly different (P<0.01) . 4. Impacting of acupuncture over diabetes big rat of heart than weight: there are a very significant difference each group than the control group (P<0.01) , Acupuncture group compared with the model group were significantly different (P<0.05)5. Impacting of acupuncture over diabetes big rat of Ang II: there are a very significant difference each group than the control group(P<0.01), Acupuncture group compared with the model group were significantly different (P<0.05) .Conclusion: 1. The result determining the various index demonstrates the item invest: making the successful big rat of model carried out an acupuncture is able to make blood sugar coming down on an empty stomach obviously, to make blood TG,CH descend obviously. It can improve the big rat oxidation resistance and restrain the big rat body inner activity oxygen loss, improve the organism metabolism condition.2. Ang II──cardiac muscle inflammation factor of experimental diabetic big rat hasbeen down regulation by acupuncture , acupuncture also has reduced heart than weight, mechanism of action was revealed profit. |
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