Coagulation Characteristics Of Adult Acute Leukemia Diagnosis

Background: To evaluate acute leukemia, which presented disseminated intravascular coagulation(DIC). Methods: By analyzing 161 newly diagnosed acute leukemia patients, we investigated clinical and laboratory features of leukemia-associated DIC . Results: Disseminated intravascular coagulation was defined by International Society of Thrombosis and Hemostasis criteria (ISTH) .A total of 71 patients (44.1%) were diagnosed with DIC according to the gold standard. Leukemia-associated DIC is characterized by no relevance of the platelet count for the diagnosis DIC and was common found in the early staye of ALL,APL and AML. Disseminated intravascular coagulation was more often associated with bleeding manifestations in acute myelogenous leukemia cases than in acute lymphoblastic leukemia cases. The frequency of acute myelogenous leukemia-associated DIC higher than acute lymphoblasticleukemia (ALL). Although prothrombin time, plasma fibrinogen, correction value and D-dimer were significantly different for patients with and without DIC. It is recommended that all patients with leukemia be investigated for DIC at presentation.