Ischemic Stroke In Patients With Platelet Aggregation Rate And Cd62p Change And Anti-platelet Drugs To Its Impact

Object:To study the influence of different anti-platelet drugs on the expressions of platelet activation markers in patients with acute cerebral infarction aspirin and ADP antagonist and provide reliable theoretical references for the prevention and therapy of acute cerebral infarction.Methods:Flow cytometry was used to examine CD62P,the platelet activation markers in patients with cerebral infarction respectively in the treatment of drug use before and six months after the ischemic stroke.The use of turbidity of the arachidonic acid(AA),adenosine diphosphate(ADP) and epinephrine(EP)-induced platelet aggregation were measured in the patients with ischemic stroke.In the administration before and after the use of drugs in three months,Modified Rankin Scale and Barthel Index were used to evaluate the neurological function of the patients of ischemic stroke.Results:The expressions of platelet activation markers in one hundred and twenty-eight patients with acute cerebral infarction were obviously higher.The expression of platelet activation markers in acute cerebral infarction patients with diabetes and hypertension was not higher than that in acute cerebral infarction patients without diabetes and hypertension.There was no significant difference between them (P value＞0.01).Both aspirin and ADP antagonist could inhibit the expression of platelet activation markers,but there was no remarkable difference between them(P value＞0.01).ADP antagonist could inhibit ADP-induced platelet aggregation more than aspirin.There was significant difference(P value＜0.01).However,the score of neurological function after treatment with the patients of aspirin group has no significant difference between the score of the patients of the ADP antagonist(P value＞0.01).Conclusion:1.The activation of platelet plays a main role in the pathogenesis of acute cerebral infarction.Whether hypertension and diabetes occurred in the ischemic stroke further promote platelet activation still needs to be further explored.2.Both Aspirin and ADP antagonist could inhibit the expression of platelet activation markers and prevent relapse in acute cerebral infarction patients.3.Different anti-platelet drugs could inhibit platelet activation and aggregation from different channels.Monitoring indicators of platelet activation(CD62p) and the aggregation can make the use of antiplatelet drugs better.We could reduce platelet aggregation and avoid the occurrence of adverse reactions.