Fungal Ball Sinusitis Clinical Analysis And The Role Of Fungi In Chronic Sinusitis And Nasal Polyps

Objective To summarize the diagnosis and treatment of fungus ball nasosinusitis by analysising 42 cases of fungus ball nasosinusitis.Method A retrospective study on 42 cases of fungus ball nasosinusitis in my hospital from 2000～2007 was performed. To summarize the patients' information, clinical manifestation, physical sign, imaging and method of healing.Result Patients were followed up for 6 months to 6 years, all patients feel good. Three patients can be washed down incrustation from antrum maxillas. Amphotercin B was given to wash antrum maxillas. 39 patients are cured, 3 greatly improved .Conclusion Pathological examination and CT scan are valuable for diagnosis on fungus ball nasosinusitis; FESS is effective in treating of fungus ball nasosinusitis. Antifungal agent can be use in the cases of larger extent of disease. Objective To investigate the relation of fungi and chronic rhinosinusitis (CRS) and nasal polyps.Method This study was divided three groups, two groups were the experimental group: Nasal mucus membrane and nasal polyps were collected from patients with CRS and with polyps, and the third was the control group, nasal mucus were collected from processus anconaeus. Fungal-specific PCR were performed on each sample, and then PCR analysis was performed. X~2 analysis was used to test for statistical difference between these groups .Result PCR technique detected fungal DNA were 32.14% and 36.00% in nasal polyps and nasal mucous membrane respectively, and 18.18% in normal control subjective. There were increase tendency in CRS and polys groups .Conclusion Polymerase chain reaction assay appears to be able to detect fungi in chronic rhinosinusitis. Fungi can be detected in the nasal mucus membrane. Fungi may be implicated in the pathogenesis of most chronic rhinosinusitis.