| Objective:This research,through 1000 clinical data and cultural heritage sorting analysis,analyzed blood-designate elements of TCM(traditional Chinese medicine) and its distribution,which are acquired by the usage of Mathematical Statistics,in order to provide related reasons with a view to the establishment of Chinese medicine syndrome dysfunctional uterine bleeding(DUB) quantitative diagnostic criteria.And through the 31 cases of DUB patients with a clinical observation,it hoped that the establishment of TCM DUB Syndrome diagnostic criteria would provide quantitative basis.Methods:1.At the beginning of this research,we looked back to the literature of Chinese Medicine Information Library of the China Academy of Chinese Medical Sciences before the Revolution of 1911.There were also some official publications relating to the ancient gynecological diseases.Through the collections and the researchs from predecessors,we has developed DUB TCM Syndrome questionnaire and has built up a DUB database,and we used the statistical software-spss13.0 to analyzed the 1000 cases of DUB patients with reactive attending the four-frequency information,taken clustering and factor analysis,determined the group with symptoms of DUB,and analyzed blood-designate elements of TCM(traditional Chinese medicine) and its distribution.Meanwhile,discuss the relationship among the DUB complication,the lab index and the DUB characters of TCM.2.Further,according to the statistics analysis,we made clinical observation to 31 patients with DUB of qi and blood deficiency at random.We used supplementing qi and nourishing yin prescription and progesterone to make clinical observations,and compared the effect between the two groups,so as to certificate the qi and blood deficiency-DUB characteristics by the means of Mathematical Statistics.Results:1.Through the frequency analysis to 1000 example clinical material,the main symptoms of the highest frequency are as follows:a blood clot,menstrual＞14 days of menstruation,the An-color red,menstrual continued the bright red color, and the frequency of 35%or more.The main symptoms of the higher frequency are as follows:weakness,dizziness,fatigue,lumbar pain,shortness of breath, and more dreams,less sleep,looking white,palpitation,languishment,upset, the frequency of occurrence in more than 20%.The main symptoms are as follows: thin tongue,white,yellow,tired,and tongue-shaped,fat,light red,heavy pulse,small veins,vein string,unable to veins,pulse a few,weak pulse.2.DUB elements of the syndrome can be concluded in three areas.According to 1000 example of DUB clinical mathematical statistic result,and differentiating from the level of causes,there are the sub-Exogenous and internal injuries,and DUB elements are wet,cold,seven emotions,and so on.Differentiating level from eight key link analysis,DUB has elements of the syndrome of yin deficiency,yang deficiency,excess heat,deficiency heat,excessive-cold,asthenia-cold, intertwist of cold with heat and so on.Differentiating level from qi-blood and body fluid,DUB elements are qi deficiency,blood deficiency,blood stasis,qi stagnation,blood heat,qi stagnation and blood stasis,qi deficiency and blood stasis,qi-blood deficiency,qi failing to control blood,water retention within body,body fluid asthenia,and so on.Differentiating from the viscera,DUB has elements of the syndrome of kidney qi deficiency,kidney yin deficiency, kidney-yang deficiency,kidney essences insufficiency,spleen qi deficiency, spleen yang deficiency,sinking of middle energizer,failure of spleen to control blood vessels,cold-dampness impairing spleen,dampness-heat retention spleen, liver qi stagnation,deficiency of liver yin,liver-blood deficiency,deficiency of both heart and spleen,blood deficiency in the heart and liver,liver-kidney yin deficiency, disharmony of the heart and kidney,the discord of the spleen and the liver,debility of Chong Ren meridians,Chong and Ren channels stasis,Chong and Ren channels thermal disturbance,impairment of chong and renchannels,and so on. 3.Through rapid method of using cluster samples,we can divide 1,000 cases of reactive blood Syndrome into several types,for example,qi-deficiency type, deficiency of both qi and blood type,liver- qi depression and spleen-deficiency and blood -thermal type,deficiency of both qi and yin type.In the 1,000 cases,the majority were deficiency of both qi and blood type,which taked a percentage of 46.2%,the percentage of deficiency of both qi and yin type was 30.9%,the percentage of qi-deficiency type was 19.8%,and the percentage of liver- qi depression and spleen-deficiency and blood -thermal type was 3.1%.The dialectic points qi-deficiency type were constant menstrual blood,over 14days menstrual period,blood clot,thin fur,yellow fur.The dialectic points of deficiency of both qi and blood type are over 14days menstrual period,blood clot,dizziness, hypodynamia,whitish fur,thin fur,veinlet.The dialectic points of liver- qi depression and spleen-deficiency and blood -thermal type were over 14days menstrual period,blood clot,hand-foot cooling,thirst with desire for drinks,palpitation, vexation,short breath,irascibility,soreness,burnout,hypodynamia,light nail color,Spirit Tiredness,sleepiness,impetuosity,fading tongue,ecchymosis or petechia or tongue,yellowish fur,greasy fur,wiry pulse,slippery pulse.The dialectic points of deficiency of both qi and yin type were constant menstrual blood, hyper-menorrhea,bright red menstrual,blood clot,burning sensation of five centres, dry mouth,waist-knee aching,extremities burnout,hypodynamia,white tongue coating,thin fur,deep pulse,rapid pulse.Experts on the DUB of Chinese medicine syndrome paid their attention on qi-yin deficiency,qi-blood deficiency,blood deficiency heat,blood stasis and so on.4.From all types of DUB on Chinese medicine syndrome type analysis,the difference was significant(P＜0.0001).In menorrhagia,hypermenorrhea,LPD, irregular shedding of endometrial the deficiency of both qi and yin type are in the majority with a very significant difference(P＜0.0001).In menometrorrhagia, metrorrhagia the deficiency of both qi and blood type was in the majority with a very significant difference(P＜0.0001).In Ovulation Bleeding,the qi-deficiency type was in the majority with a very significant difference(P＜0.0001).5.From 1,000 clinical materials of DUB,adolescent patients suffering from deficiency of both qi and blood type were in the majority,which was 41.35%,the qi-deficiency type was 21.80%,the deficiency of both qi and yin type was 36.84 %,and there was no the liver- qi depression and spleen-deficiency and blood -thermal type:Patients in the family way suffering from the deficiency of both qi and blood type were in the majority,which was 48.10%,the deficiency of both qi and yin type was 30.90%,the qi-deficiency type was 16.46%,and the liver- qi depression and spleen-deficiency and blood -thermal type was 1.3%:Patients in climacteric suffering from deficiency of both qi and blood type were in the majority, which was 44.37%,the qi-deficiency type was 28.87%,the deficiency of both qi and yin type was 19.01%,and the liver- qi depression and spleen-deficiency and blood -thermal type was 7.75%:From the distribution,the main tpye of the three age groups was deficiency of both qi and blood type,and the proportion of adolescent patients with deficiency of both qi and yin type was more than that of growth period and that of the climacteric,and the proportion of liver- qi depression and spleen-deficiency and blood -thermal type was the minimum:the proportion of patients in climacteric with liver- qi depression and spleen-deficiency and blood -thermal type was more than that of growth period and that of adolescence.6.In the term of laboratory indices,through the analysis of variance,Hb in all types of Syndrome had no significant differences(P＞0.05),but PLT had significant differences(P＜0.05).The PLT qi-deficiency type was the highest,the deficiency of both qi and yin type was the lowest,and the qi-deficiency type was significantly higher than that of the deficiency of both qi and yin type.There were no significant difference(P＞0.05) in four parameters of blood coagulation PT,but the qi-deficiency type was the highest,the deficiency of both qi and yin type was the lowest.There were significant differences(P＜0.05)in Flag between liver- qi depression and spleen-deficiency and blood -thermal type and qi-deficiency type, namely the DUB qi-deficiency type was the highest,the liver- qi depression and spleen-deficiency and blood -thermal type was the lowest,while there were no significant differences(P＞0.05) between deficiency of both qi and yin type and deficiency of both qi and blood type.APTT and TT in all types of Syndrome had no significant differences(P＞0.05).In APTT,the liver- qi depression and spleen-deficiency and blood -thermal type was the highest,the qi-deficiency type was the lowest.In TT,the liver- qi depression and spleen-deficiency and blood -thermal type was the highest,the qi-deficiency type was the lowest.Through the variance analysis of the blood serum of patients,the results show that P content was the highest power in the patients with deficiency of both qi and blood type,and had significant differences(P＜0.05) with the deficiency of both qi and yin type.There were no significant difference(P＞0.05) among PRL,FSH,LH,E2,T types of syndromes.7.Through the 31 cases of the patients with deficiency of both qi and yin type,We used supplementing qi and nourishing yin prescription and Progesterone to make clinical observations,and compared the effect between the two groups.We discovered that there were significant differences between the treatment group and the comparison group on the improvement in symptoms,Hb,APTT and TT.But there were no significant difference between the two groups in menstrual and total efficiency,physical and chemical check indicators.It's proved that in accordance with the first part,which is about statistical analysis of the DUB characteristics have some reliability.Conclusion:1.This research makes a conclusion that there are relations between the TCM Syndrome Elements and characteristics and the laboratory index and syndrome,through 1,000 literature and analyzed clinical data.2.The person,surffering from deficiency of both qi and yin,and taking the benefit after having a supplementing qi and nourishing yin prescription and his symptom, has been improved better than having Progesterone.Through further validation from the reverse by means of mathematical statistics,we can make sure of the characteristiscs of deficiency of both qi and yin type-DUB,and those are reliability and practicability.3.Not only because this study has mathematical statistics as a basis,but also further clinical information has been verified,it offers data support and makes a role model for the research of the syndrome diagnostic criteria.The study of DUB syndrome study conducted in a large sample case,and the use of mathematical statistics can get the DUB clinical disease cards of suffers,which are representational and universal,so it makes the result more reliable,and it provides the standards of quantitative diagnosis of TCM Syndrome and makes a exemplary role. |
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