.200 Patients With Chronic Obstructive Pulmonary Disease Pathogenesis Clinical Research

Chronic obstructive pulmonary disease (COPD), is a disease that characteristics of restricted flow, its not entirely reversible airflow restricted, deteriorated with the development of disease, related to abnormal inflammatory response that caused by harmful gases or harmful particles. COPD is a devastating lung disease, the frequently-occurring disease in the world, common disease, with high morbidity, disability and death rates. Modern medicine for the treatment or prevent of COPD or delay the deterioration of lung function, improve or stabilize patients with clinical symptoms and prevent serious complications for the primary purpose, but the effect not ideal, the effect of Chinese medicine on the treatment of COPD has been affirmed, it has practical significance that explorate Chinese medicine on the pathogenesis characteristics of COPD.Objective:To discuse the pathogenesis , provide a theoretical basis of prevention and treatment on COPD by collecting the clinical data of patients with COPD.Methods: Starting with certification from the disease, used epidemiological survey methods, based on "973" program subject - Syndrome norms and system of dialectical method - Syndrome elements - Clinical Epidemiology cross-sectional survey - chronic obstructive pulmonary disease clinical information questionnaire, to formulate a unified four consultation questionnaire with appropriate modifications , collecting clinical data in acute and stable period with COPD patients. The data will be entered into the computer after collected and processed, analysised with SPSS15.0 statistical package . to dialecte COPD pathogenesis with theoretical knowledge of TCM on the analysised results, to discuse the pathogenesis , provide a theoretical basis of prevention and treatment on COPD(rspiratory a deputy director in more than doctors conducted with the assistance of data acquisition). All the patients from department of Respiratory in Chinese medicine hospital of Hubei Province and the first hospital of Wuhan during September 2006 to November 2007.Results: (1) Pathogenesis in acute phase: lung Tanshi resistance (64) cases, Tanreqing Yun-lung (55) cases, Yang phlegm and blood stasis (51), and the Waixiefanfei (30) cases; Stable phase: Lung Qi (50) cases, Feishen deficiency (85) cases, phlegm and blood stasis resistance lung (65) cases. (2) Gender have statistically significant to this disease. Male prone to COPD more than femal. (3) different age groups of this disease have differences. Pathogenesis in acute phase mainly to Tanshi lung, Yang phlegm and blood stasis, Yun-lung Tanreqing increased with age; while stable phase lung Qi, Feishen deficiency, phlegm and blood stasis with lung resistance increased with age too. (4) incentives, previous history, personal history (smoking, risk factors), education, family history have an impact on the incidence of COPD. (5) laboratory tests (lung function, chest film or lung CT) showed that the classification of lung function have an impact on COPD, COPD patients have different degrees of lung damage.Conclusion: Based on 200 patients with COPD clinical research results show that: (1) The incidence of this disease to lung spleen and kidney deficiency-oriented, outside evil invased lung, pathological production obstructed lung meridian, lung missed raise and drop, recurrent disease, refractory impaired. Locattion of disease is in the spleen and kidney, disease-based virtual machine features standard is: acute disease is the main standard to both the virtual to the evil cold, sputum wet, sputum heat and congestion as the main risk factors. cold , sputum wet, sputum heat and congestion is the mainly cause of disease. (2) than male-female incidence. (3) elderly patients with more morbidity. (4) COPD incidence of seasonal characteristics to the incidence in winter and spring mainly to the evil Fanfei mainly cold. (5) COPD incidence of smoking is a major incentive in the acute stage, smoking the drug more easily lead to fire Tanreqing Yun-lung. (6) poor working environment, poor physical, low level of education, family history of genetic groups more prone to COPD. (7) laboratory tests: lung function, lung CT chest film or the results showed that the lung damage have an impact on the incidence of COPD.Pathogenesis in acute phase: Risk of lung function in patients with mild Waixiefanfei, lung function in patients with moderate risk Tanreqing Yun-lung, and severe, very severe lung function in patients with risk Yang phlegm and blood stasis.lung damage more severe, in patients with clinical symptoms also seen more severe, the longer the course, the more Refractory.