Integrative Medicine Clinical Study Of Treatment Of Diabetic Nephropathy

ObjectiveTo study the clinical effect and safety of Jin Kui Shen Qi Wan and Shui Lu Er Xian Dan curing Diabetes Nephrosis clinical nephrosis time .To appraise the clinical curative effect and measure the security of Jin Kui Shen Qi Wan and Shui Lu ErXian Dan by comparing with western medicine, All the conclusion is to be offered scientific basis for clinical application.Methods64cases patients came from Hu Bei College of Traditional Chinese Medicine in February, 2006 - February, 2008 who are diagnosed as Qi Deficiency of Spleen and Kidney,Yang Deficiency of Spleen and Kidney. 64cases patients are divided into the control group (32 examples)and the treatment group (32 examples)in stochastical, parallel and comparison principle. Before two groups of patients accepting treatment, the age, the sex, the course, the main Chinese medicine symptom and so on quite even have no the significance differences, two groups have the commeasurability. Patients in two groups accept the diabetes health education, the control diet, the suitable movement, and the high quality low protein diet (0.6g/kg.d), the control group accept the western medicine treatment: Diovan is given to control the blood pressure ,Ge Lie Kui Tong is given to control the blood glucose ,the Fluvastatin is used to to be to adjust the blood fats. Treatment group: on the base of the control group, patients acceptthe traditional Chinese medicine dialectical treatment with Jin Kui Shen Qi Wan and Shui Lu ErXian Dan.Moreover, patients who are diagnosed as Yang Deficiency of Spleen and Kidney are given to Dang Shen ,BaiZhu,Huang Qi.Patients who are diagnosed as Yang Deficiency of Spleen and Kidney are given to Gan Jiang,Du Zhong,Xian Ling Pi. Patients with blood stasis could be given to herbal with activating blood and resolving stasis such as Dan Shen ,Hong Hua,Yi Mu Cao.Cook herbal with water.Patients in treat group take herbal decoction 200ml every time and twice one day.One treatment period is 30 days for each group.Observation target and method: Observe the main clinical symptoms around observation treatment, fill in clinical observation table.Exame 24 hours urine protein,blood urea nitrogen,serum creatinine,fastingblood glucose,blood glucose 2 hours after meal,bloodroutine, stoolroutine.Statistics processing: The complete data uses SPSS for the Windows13.0 edition to carry on the analysis, the remarkable level takesα=0.05. All statistical test uses the two-sided test, P<0.05 means that there is statistics significance in the differences examined; P>0.05 examines means that there is non-statistics significance in the differences examined. T-test is used in the measurement material, chi-square test is used in the counting material.Result1. The control group : 11 examples are distinctive , 13 examples are effective, 8 examples are invalid in reducing 24 hours urine protein and improving kidney function, the total effective rate is 75.00%. The treatment group: 11 examples are distinctive, 14 examples are effective, 7 examples are invalid, the total effective rate is 78.13%.There are distinctive differences between two groups by statistics processing(P<0.05).2. The accumulative mark of both groups decreases after treatment in the related Chinese medicine symptoms. there are distinctive differences between two groups on the accumulative mark in the related Chinese medicine symptoms after treatment(P<0.05).3. The related Chinese medicine symptoms of both groups are improved after treatment.The improvement of the treatment group on symptoms of fatigue,lumbar and knee soreness,edema is more distinctive(P<0.05).4. After a treatment ,the blood glucose of two groups is controlled, but there is no distinctive differences between tow groups (P>0.05).5. Safety inspection:There is not abnormal change in bloodroutine,stoolroutine after one treatment . There is no untoward effect or anaphylactic phenomenon in the clinical practice.It means that Jin Kui Shen Qi Wan and ShuiLu Er Xian Dan is safe and effective.ConclusionJin Kui Shen Qi Wan and ShuiLu Er Xian Dan with western medicine to treat diabetes nephrosis clinical nephrosis time can improve the kidney function and reduce 24 hours urine protein,improve some Chinese medicine symptoms such as fatigue,lumbar and knee soreness,edema.Furthermore,it is safe and effective.All these indicate that it is worth to study and promote.