| Objective:Observing the curative effect of the traditional Chinese herb medicine nongqinpian on chronic prostatitisMethods:All objects observed are outpatient attendance in various research units from November 2005 to November 2006,A total of 442 cases,Male,Age 18 to 50 years old,Diagnosis into line with standards,Voluntary medication and signed informed consent.By the principle of randomized,controlled,336 cases divided into the treatment group(nongqinpian)and the control group(Placebo)106 cases Case selected standards1.Male2.Age 18 to 50 years old3.Meet the Western Medicine diagnostic criteria for chronic prostatitis and4.Meet the traditional Chinese medicine 5.Signed informed consent Diagnostic CriteriaWestern medicine diagnostic criteria1.Symptoms:Frequency,urinary not,perineum,lower abdominal pain,etc.2.DRE:Prostate surface is uneven or asymmetrical,irregular touched inflammatory sclerosis,and tenderness.3.Prostatic fluid(EPS)inspection:WBC＞10/HPF lecithin or reduce body.4.Ultrasonic Inspection:Section slight deformation,but many do not expand,not the entire capsule punch,not consecutive.Have one,the exclusion of other diseases can be diagnosed.TCM diagnostic criteriaHygrothermal Wenjie and bleeding cardThe most important Symptoms:1.Urgent urination frequency,urethral burning and urine after Ms Lek.2.Shaofu,perineum,lumbosacral pain or discomfort.The less important Symptoms:1.Scrotum humid.2.After drops of urine. Tongue clock:Tongue red or stasis,Yuban,Moss yellow or yellow greasy,or slip a few veins Yuen.All of the above have 1 or 2,as well as in the times of a reference clock tongue, Differentiation and bleeding for the hot and humid Wenjie card.Medication methodsTest group:nongqinpian PO 6/2 times/day course of four weeks.Control group:Placebo PO 6/2 times/day course of four weeks.Outcome MeasuresEffect of the main indicators(1)chronic prostatitis symptom index(NIH-CPSI)score(2)TCM hot and humid Wenjie and gore permit symptoms Points(4)individual symptomsResult:①NIH-CPSI score efficacy analysisAfter four weeks of the test group NIH-CPSI score mean for 11.63±4.7906, TCM control group,the mean score in 17.44±4.6723,the test group and control group,the difference was significant(p=0.0000),and two weeks after treatment Before treatment margin,the test group and the control group were 10.83±5.739 and 4.37±3.473,drop test group than the control group,and within the group between group differences were statistically significant(p=0.0000).After four weeks of NIH-CPSI single symptom score,the test group and control group of positive symptoms less than test,the test group fell more than the control group,the difference between the two groups is statistically significant(p＜0.05).②The effect of TCMtest group 82.4%total efficiency,the control group 40.6%total efficiency,the test group compared with the control group,the experimental group total effective controls,a statistically significant difference(p=0.0001).After four weeks of the test group integral mean 9.8690±3.9543,control group integral mean 14.43404±4.1427,The test group compared with the control group, There was significant difference(p=0.0000),4 weeks after treatment and before treatment margin,the test group and the control group were 9.51±4.55 and 4.88± 4.40,higher than that of the experimental group,the group with the difference between groups were statistically significant(p＜0.05).③individual symptoms improvedSymptoms include individual Chinese urgent urination frequency,and urine after Ms Lek not,burning urethra,perineum,Shaofu,lumbosacral pain or discomfort, humid and scrotum after drops of urine,after 4 weeks of treatment symptom scores than before treatment by the decline in the test group fell more than the control group, after treatment with the group before and after the treatment group compared the differences were statistically significant(p＜0.05).④Safety EvaluationAfter the two groups of vital signs(systolic blood pressure,diastolic blood pressure and heart rate)before treatment and little change,differences within the group no significant difference(p＞0.05)。Experimental adverse events occurred in 15 cases,of which 12 cases of the test group,the rate was 3.3 percent,the control group three cases,the rate was 2.5 percent, between the two groups in rates of adverse events there is no significant difference (p＞0.05),And drug-related adverse events may be three cases,the pilot group and the control group were two cases and one case.Between the two groups incidence of adverse events there is no significant difference.Conclusion:Nongqinpian can effectively improve chronic prostatitis urgent urination frequency symptoms,and improving the quality of life and better security. |
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