Detoxification Mixture Of Yiqi Qingwen Demolition Side Of The Influenza Virus Fm1 Infection Caused By The Intervention Of Immune Damage And Repair Mechanisms In Mice

Acute inflammatory injury is the main reason of causing severe systemic symptoms and severe pneumonia and even death by influenza virus,as well as the important reason of acute lung injuty even death by other respiratory tract virus,such as SARS.In the immunity regulation networks of infection body, the foundation of causing immunity injury are the abnormal increasing of inflammatory factors.Therefore, the inflammatory factors intervention has the important significance and application prospect to decrease the mortality rate and damaged degree of influenza and other respiratory tract virus'infectious disease.Flu belongs to"epidemic cold"in traditional Chinese medicine (TCM)theory, one of exogenous febrile diseases. So far the doctors of TCM have accumulated rich experiences in prevention and curing for eternal febrile diseases by different ways with advantages.With the guard of Pro.Jiang, the research group get rich knowledge and clinical experiences. Based on the fruits of the past and the great deal of reviews, we hold that"exogenous cold and seasonal epidemic poison with internal stagnant toxic heat is the main cause of flu in the northern region; the general pathological mechanism is eternal cold with internal heat and stagnant toxic heat. So the therapeutical principle is"expelling cold and clearing away heat, replenishing qi and dispelling toxin. The formμla is YQQWJDHJ (YIQIQINGWENJIEDUHEJI) composed of frying Ma Huang (Ephedra Herb),raw Shi Gao (Gypsum),Chai hu(Chinese Thorowax Root),Huang Qin(Baical Skμllcap Root),Ying Hua (Honeysuckle, raw Huang Qi (Mongolian Milkcetch Root) etc. The study aimed at appraising the curative effect of YQQWJDHJ via clinical observation and experimental research of its separated parts.Experimental research: to study mechanism of the 4 parts of forming of YQQWJDHJ by observing the action of them on the cytokines and the pathology of lung tissue of the model rats infected by IV. Resμlts:(1)The model group : The most serious lung tissue inflammatory injury is On 3rd ,5th day after infecting.(2)The group of clearing away heat and poison:the lung tissue is lighter than the model group,the efficacy is the most significant in the four separated groups.(3)The group of replenishing Qi: the lung tissue is serious injury on 1rd ,3th day after infecting,but becomes lighter on 5rd ,7th day after infecting.(4)The Group of relieving superficies with acrid-cold herbs:it is serious injury on 1rd ,3th day after infecting,but becomes lighter on 5rd ,7th day after infecting.(5)The Group of relieving superficies with acrid-warm herbs: it's serious injury On 3rd ,5th day after infecting,but repaired later. Conclusions: The group of clearing away heat and poison in YQQWJDHJ is the main method to intervent and repair the lung'inflammatory injury On 3rd ,5th day after infecting.It is the outstanding method in YQQWJDHJ.