| The experiment is on the ground of theory that aging is resulted byfree radical injury. This theory deem that the free radical produced in theprocess of metabolizing can react upon protein, phospholipid or nucleicacid, and the consequent result can injure structures and function of cells,and the damage accumulation can result in aging. With body aging, the rateof producing free radical is going up, but the activity of anti-free radicalenzyme is reducing. The unbalance between oxidizing and reducing ischaracteristic of living beings aging. The free radical is one of the mostimportant factors that leads to the organism injury and tiny-environmentchange of tissues. Therefore, reducing the rate of producing free radical andthe damage from free radical, contributing to the repair of free radicalinjury may have effects on aging.In traditional Chinese medicine, Qi is considered as an energy witch isa motive force for viscera physiological functions. Qi can produce blood,propel blood, make phlegm melt, make stagnation clear. So the deficiencyof Qi should be the major factor witch causes impairment or weakness oforgans as well as aging.Objective: To observe antagonizing free radical injury ofStomach-Health-2 (SH2)Methods: 25 male mice were divided into 3 groups by random:normal control group, model control group and SH2 group. model controlgroup and SH2 group were treated with 10％D-galactose(D-gal) (thedosage was 140mg/kg·d) once a day for six successive weeks bycervicodorsal region subcutaneous injection to establish D-gal aging micemodel, While the mice of the normal control group were treated with samedosage water instead,the SH2 group with SH2 through pouring intostomach.After six weeks, the malondialdehyde(MDA) content and SOD activity in serum,liver and gastric mucosa of mice were measured.Results: In the model control group, the MDA content in serum, livertissues and gastric mucosa was significantly higher(serum,liverP＜0.05;gastric mucosa P＜0.01)and the SOD activity was significantlylower(P＜0.05) as Compared with normal control group. The MDA contentwas significantly lower and SOD activity was significantly higher in serum,liver tissues and gastric mucosa of SH2 group (P＜0.05) compared with themodel control group.Conclusion: SH-2 can antagonize free radical injury, increase SODactivity, decrease MDA content in serum, liver tissues and gastric mucosa.SH-2 may have anti-aging effects at through antagonizing free radicalinjury. |
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