Compound Danshen Dripping Pills In Hypertensive Patients

Objective: On the basis of Chinese Medicine theory which is diagnosing and treating on the basis of an overall analysis of the illness and the patient's condition, to observe the influence of different treatment on the masculine patients who was sufferred Hypertension and blood stasis to blood pressure,lipidemia,symptoms and the CCAIMT, compare the effect of treatment of Chinese Traditional Medicine Compound Danshen Dripping Pills combinate with Western medicine calcium channel blocker Nifedipine and assoluta Nifedipine, and parallel observe the security of curative medication, explore the superiority of the kind of Chinese Traditional medicine of ABTBS as CDDP in treating EH and blood stasis, and explore the influence to target-organ damagement which was aroused by Hypertension. Consequently establish foundation for more extend and application of CDDP in cardio-vascular disease, and break the routine that CDDP just cure CHD, dig adequately development potention of Chinese Medicine in cardio-vascular domain, and the same time, provide scientific evidence for more exploitation and research of Chinese Medicine preparation. Method: We adopt clinic research. Choose the masculine patients who was sufferred Hypertension and blood stasis from the first hospital of Wuhan during 5, 2005 to 8, 2006. 61 sufferers were divided into two groups at random by adopting the airtight envelope law. CDDP combinate with Nifedipine group with 30 patients and-Nifedipine group with 31 patients. After pausing all drugs one week, treasure blood pressure sedentarily, carry out ABPM, examine CCAIMT by ultrasonic and detect lipidemia and security indexes of curative medication, then start treatment, during the treating period all drugs which may infect blood pressure and lipidemia were paused, and detailedly note bad feedback. The observation term was six months. After treating one month, treasure blood pressure sedentarily and note. When the period of treatment finished, treasure blood pressure, carry out ABPM, examine CCAIMT, detect lipidemia again and note ameliorate instance of patients' symptoms after treatment. Compare the indexes before therapy with after therapy in group, and compare different treating methods between groups. Analyse statistically computation data by t-test, and enumerative data byχ~2-test.Result: The age,couse of diseases,commence blood pressure and lipidemia of patients of two groups all haven't statistical differentia. The indexes of security of all patients found haven't serious poison and side-effect. Nifedipine group had one patient quitted for edama of two legs, and the combination group of Chinese medicine and western medicine had less number of bad feedback than assoluta Nifedipine. When treated one month, the blood pressure of two group all had descended to natural range, and two groups had reasonably effect (P＞0.05), and all had remarkably differentia compared with before therapy (P＜0.01). When the period of treatment finished, the two groups had reasonably reversing rate of blood pressure day and ninght rhythm. There were no statistical differentia between two groups. The CCAIMT in combination group had became thinner than before, when compared with before therapy had remarkably statistical differentia (P＜0.01). But the CCAIMT in group of western medicine hadn't distinct melioration, and compared with before therapy had P＞0.05. There were statistical differentia between the two groups (P＜0.05). The lipidemia of the combination group all had distinct meliorate, and had remarkably statistical differentia (P＜0.01). But the western medicine group hadn't distinct meliorate after treatment. Comparing the two groups had statistical differentia(P＜0.05)after treatment. The effective rate of two groups hadn't remarkably differentia in the effect of melioration of symptoms (P＞0.05).Conclusion: The age,couse of diseases,commence blood pressure and lipidemia of patients of two groups all haven't statistical differentia, that indicated the two groups were comparable. From the results of determination we had conclusion as follows: all patients hadn't serious bad feedback which indicated the two drugs had widely application range in clinic; Chinese Medicine of ABTBS as CDDP could treat EH and blood stasis, combinating with Nifedipine could descend blood pressure, correct blood pressure day and night rhythm, meliorated lipidemia and CCAIMT. Consequently it could reverse vascular remodeling of Hypertension, and prevent and cure target-organ damagement, the effect of meliorating lipidemia and CCAIMT was assoluta Nifedipine hadn't; emboded the worthiness of CDDP in cardio-vascular diseases. In addition, This research took full advantage of soul of Chinese Medicine which was diagnosing and treating on the basis of an overall analysis of the illness and the patient's condition, and embode the trend of joint of Chinese Medicine theory and modem medical science, at the same time, established foundation for more exploitation and research of Chinese Medicine.