Tin Yiu 0604 To Promote The Role Of Rat Skeletal Muscle

OBJECTIVE: To study the main pharmacological effects of Tianyao0604(TY0604) for speeding-up skeletal muscle development by experiment. METHODS: From the rotate pole instrument of mice and rat established the fatigue model in increasing sporting load training.After training four weeks killed rats, determined the content of TC, TG, HDL, NEFA, Lactic Acid, Testosterone in serum and Protein, RNA in lower limbs skeletal muscle(gastrocnemius muscle and soleus muscle and plantar muscle). After selecting a the most effective drug TY0604 by the experiment of resistant sport fatigue,50 male Wistar rats were randomly divided into 5 groups: a vehicle control group,a fatigue model group,and three treatment group(TY0604) were supplied by irrigate gastric every day and the same volumetric 5% CMC were supplied vehicle control group and fatigue model group. Three treatment groups were an obvious improvement in the exhaust time, an significant decrease of Lactic Acid, and there were significant increase of RNA and protein and Testosterone as compared with that of training control group by resistant sport fatigue experiment ,and TY0604A was the best effect than other treatment groups. The pharmacodynamics research of TY0604A indicate that high-dose was significantly higher than fatigue model group in the exhaust time, protein, RNA and weight coefficient of the lower limbs skeletal muscle(gastrocnemius muscle and soleus muscle and plantar muscle),but a lower level than vehicle control group. Contents of NEFA and Lactic Acid were obvious lower than fatigue model group, and an increase of food intake, weight, kidney coefficient, Testosterone. CONCLUSION: TY0604A could increase rats' weight, lower limbs skeletal muscle, improve movement abiliTY0604 and resistant sport fatigue, speeding-up skeletal muscle development by increasing Testosterone and Protein, decreasing Lactic Acid in serum.