Benazepril And Amlodipine Intervention In Hypertensive Patients With Subclinical Vascular Disease Comparison Study

Objective To investigate and compare of benazepril and amlodiping in treatment subclincal vascular alterations in patients with essential hypertension.Methods Choose 60 patients with essential hypertension(age≥40 years old,without injury of target apparatus and obvious symptom),"cardio ankle vascular index(CAVI)","intirnal medial thickness(IMT)","flow mediated dilation(FMD)" which were associated with artery stiffnes,artery porridges sclerosis and endothelial function of artery were measured by blood pressure and pulse measure equipment and high resolution uhrasonograph,they were compared with 30 normotensive individuals as the control group;then 60 patients were divided into two groups,one groups were treated with benazepril,the other groups were treated with amlodiping. The dose of benazepril changed from 10mg to 20mg on the basis of the level of blood pressure and the effect of treatment.The dose of amlodiping changed from 5mg to 10mg on the basis of the level of blood pressure and the effect of treatment.After 12 weeks,rechecked the blood pressure and CAVI,IMT,FMD,compared with former treatment,and compare the effect of benazepril and amlodiping.Results SBP and DBP of the patients with essential hypertension is higher than the control groups(SBP:147.40mmHg±11.60mmHg vs 117.60mmHg±8.90mmHg,DBP: 96.30mmHg±6.50mmHg vs 74.60mnHg±5.20mmHg,P<0.01),CAVI,IMT is higher,FMD is lower than the control groups before treatment(CAVI:9.60±1.20 vs 7.20±1.40,P<0.001;IMT: 0.68mm±0.02mm vs 0.61mm±0.01mm,P<0.05;FMD:6.30%±6.10%vs 16.00%±8.90%, P<0.05).Reflecting artery stiffnes increased,artery porridges sclerosis and endothelial function of artery was injury.After treatment ofbenazepril and amlodiping,SBP,DBP,CAVI and IMT reduce,FMD increase(Benazepril SBP:126.60mmHg±9.80mmHg vs 148.50mmHg±11.40mmHg,P<0.01;DBP:74.10mmHg±6.10mmHg vs 96.30mmHg±7.40mmHg,P <0.01;CAVI:7.30±1.40 vs 9.62±1.20,P<0.01;IMT:0.64 mm±0.03 mm vs 0.67 mm±0.02 mm,P<0.05;FMD:15.00%±9.50%vs 6.40%±6.00%,P<0.05 Amlodiping SBP: 124.7mmHg±10.1mmHg vs 148.5mmHg±11.6mmHg,P<0.01;DBP:75.5mmHg±5.8mmHg vs 96.2mmHg±7.1mmHg,P<0.01;CAVI:7.4±1.5 vs 9.5±1.2,P<0.01;IMT: 0.63mm±0.02mm vs 0.69mm±0.01mm,P<0.05;FMD:14%±9.2%vs 6.3%±6.1%,P <0.05),all of them have statistical significance.But compare the effect of benazepril and amlodiping,no severe side effcet occurred(P>0.05).Conclusion Vascular alterations in patients with essential hypertension is earlier than clinical symptom and clinical diagnose;benazepril and amlodiping can reduce blood pressure, the study indicate the two drugs also can improve subclincal vascular alterations in patients with essential hypertension,no severe side effcet occurred in short-term effect.