| Objective To explore the predict factors of antihypertensive efficacy response to Benazepril treatment in essential hypertension patients. The independent variable of the current study included PP and acute antihypertensive effects in 24h after Benazepril treatment. Methods In order to elucidate genetic and environment influence on individualized response to antihypertensive, from August 2000 to December 2001, a study on pharmacogenomics in essential hypertension was conducted in District A and B, Anhui, China. The Current study was a part of it. In total, 1,244 subjects were recruited to the prospective cohort study and 1,129 of them (508 male, 621 female) completed 15-day Benazepril treatment. The clinical and epidemiological information was completed, and the data were analyzed by methods of independent variable-residual, linear regression and Logistic regression with SAS and Splus. Results (1) there was a linearity relation between PP and blood pressure decrease response to Benazepril treatment. The correlation coefficient of ASBP in male was smaller than that in female (r=0.30,p<0.01; r=0.35,p<0.01); but the coefficient of ADBP in male was bigger (r=-0.11,p<0.01; r=-0.04,p>.05) than that in female. There was a similar result after controlling the confounding factors. (2) In male, 1mmHg increase in PP was associated with 0.35mmHg(95%CI: 0.26~0.45mmHg) and -0.12mmHg(95%CI: -0.20~-0.04mmHg) corresponding to ASBP and ADBP. In female, the result was similar. It showed a dose-response relationship, after divided into groups according to the value of PP. In male and female, the highest PP group had blood pressure 9.8mmHg (95%CI:6.1~ 13.5mmHg) and 13. 6mmHg(95%CI:9. 8-17. 5mmHg) higher in SBP and 7.1mmHg (95%CI:4.2~10.0mmHg) and 4. 3mmHg(1. 8-6. SmmHg) lower in ADBP than that ofthe lowest PP group. (3) There were closely positive correlations between the independent variables and the dependent variable. The correlation coefficients of 2h, 6h and 10h in male were 0.31,0.25, 0.35,0.31 and 0.28,0.28 corresponding to ASBP,A DBP, and the 6h coefficient was the highest (P SBP<0.01, P DBP<0.05). Adjusting relate confounding factors, the researchers got the same results. (4) An increment of 1mmHg in 6h blood pressure change after treatment, in male, was found to be associated with a greater 0.41mmHg (95%CI:0.25 ~ 0.57mmHg) and 0.28mmHg(95%CI:0.11 ~ 0.46mmHg) in mid-term SBP and DBP. In female, the results were similar. Analyzed the other independent variables, we found the similar results. After divided into four groups according to the value of 6h, in female, the highest group had 14.2mmHg(95%CL:10.0~18.3mmHg) and 7.8mmHg(95%CI:5.1~10.5mmHg) higher in ASBP and ADBP than the lowest group, and a trend of dose-response was found. The other independent variables had the similar results. (5) The logistic regression results showed those, in male, the OR was 1.03(95%CI:1.01~1.05,according to SBP) and 1.08(95%CI:1.04~1.12,according to DBP) with the 6h blood pressure increasing ImmHg. After divided into four groups according to the value of 6h blood pressure fall after treatment, in female, the highest group had a higher OR (OR SBP=3.51,95%CI: 1.89-6.54; OR DBP=5.63,95%CI: 2.61-12.13) than the lowest group, and a trend of dose-response relationship was found, too. The results of other analysis were similar. Conclusion (1)There was a significant positive dose-response relationship between PP and ASBP and an inverse dose-response relationship between PP and ADBP after Benazepril treatment in essential hypertension patients of Anhui; (2) The acute antihypertensive of distinct points in 24 hours after Benazepril treatment may be valid predict indexes of mid-term decompression efficacy, and the acute antihypertensive of 6h may be the best index of them.
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