Buck Capsule Combined With Nimodipine In The Treatment Of Isolated Systolic Hypertension Clinical Study

Objective: Our aim was to observe the depressurization effect and improved condition of clinical symptoms of Jiangya capsule combined with nimodipine, discuss the mechanism in treating hypertension and influence to vascular endothelial function, hypertensive nephrine injury and arterial elasticity.Methods:We used randomized,blind and control trial. 120 males and females EISH patients from 60 to 80 years were randomly assigned to administration of Jiangya capsule combined with nimodipine group(treated group) or nimodipine group(controlledled group).Treated group taked Jiangya capsule 3 tablets tid and nimodipine 1 tablet tid; The controlled group taked nimodipine 1 tablet tid and Jiangya capsule placebo 3 tablets tid. The course of treatment was 4 weeks.Obseve the symptom cumulative scores , blood pressure, plasm NO , HS-CRP, TXB, 6-Keto-PGF-1α, ET-1, five projects of early nephrine injury (MALB,TRF,NAG,β-2MG,IGU) , blood routine, urine routine, ECG, ALT, CREA and BUN before and after the test, at the same time, fill in the Short Form-36; Test the 40 patients' ABPM and limb arterial rigidity randomly.Results: 1．Depressuriation effect.clinic BP: SBP was obviously decreased in treated group compared with controlled group, and DBP one didn't. ABPM: 24hour mean SBP, day mean SBP, night mean SBP all had obviously depression in treated group compared with controlled group, and DBP one didn't.In treated group treatment showed markedly effectively 15 cases,effectively 29 cases, ineffectively 10 cases,and total effective rate was 81．5%. There were markedly significant difference between treated group and controlled group(P<0．01) . 2．Symptom improvement: yin deficiency and yang hyperactivity syndrome in treated group had obviously effect compared with other syndromes in treated group, yin deficiency and yang hyperactivity syndrome in controlled group , and other syndromes in controlled group (P< 0．05) . 3．Quality of life: the five dimesion of PF, RP, BP, GH, SF had obviously improvement in treated group compared with controlled group (P<0．01) , VT, RE, MH had improvement in treated group compared with controlled group(P<0．05) . 4．Lab examination: after 4 weeks treatment, NO, ET-1, HS-CRP, TXB and 6-Keto-PGF-1αhad obviously improvement in treated group compared with controlled group. (P< 0．05) 5．Early nephrine injury : MALB,TRF had obviously improvement in treated group compared with controlled group(P<0．01) ; NAG,β-2MG and IGU had no significant difference between treated group and controlled group. 6．Limb arterial rigidity: after 4 weeks treatment, the PWV of both left and right limbs had obviously improvement in treated group compared with controlled group in spite of not attaining statistics significant difference; the ABI had no improvement in treated group compared with controlled group.Conclusions: 1．Jiangya capsule combined with nimodipine have better depressuriation for yin deficiency and yang hyperactivity syndrome than nimodipine. 2．Jiangya capsule combined with nimodipine can improve patients' clinical symptoms and improve the quality of life. 3．Jiangya capsule combined with nimodipine can recover the endothelial function and maybe delay the early hypertensive nephrine injury.