| Objective: Primary bronchial lung cancer is one of the most common chestmalignant tumors and the incidence of it has risen year by year considerablyand been primacy malignancy in nation in the past few years. Most of them(about 80%) are non-small-cell lung cancer (NSCLC). Operation therapy is thebest method of all,5-year survival rate of the NSCLC sufferer of early periodis higherabout 70% of incapable operation in those are the period ofⅢ,Ⅳ,moreover,about 70% of those occur relapse and metastasis.Because of the mostnew chemotherapy drugs and molecule target drugs have been developed , thetreatment effects of lung cancer have much risen.But the prognosis of suffer ofafternoon NSCLC do not reach ideality.So presently emphases of clinical studyis how to improve the quality of life, improve and control clinical symptoms.So,we select the capsule of qijiafuzheng whom is the traditional prescription ofastringent and detoxification to treat the stageⅢa to stageⅣNSCLC patientwho are treated with chemotherapy drugs according to these resources.To comp-are the response,quality of life(QOL),TCM clinical symptom, appetite and bodyweight and so on between the capsule of qijiafuzheng plus NP regimen andNP regimen alone in patients with advanced non-small cell lung cancer (NSCL-C),we want to know whether integrated TCM and West Medicine treatmentcan improve the quality of life, control clinical symptoms.Methods: fifty non-small cell lung cancer patients with diagnosis ofmedical imaging or pathologywere randomized to receive qijiafuzheng capsuleplus NP regimen(groupA n=30)or a comparator arm of NP regimen alone (group B n=20).The therapeuticplan of group A and B are as follows:Group A:The dose of Cisplatin is 60-80mg/m~2. intravenous drip in a day or in two-three days;Usage:the dose of Vinor-elbine is 25mg/ m~2. intravenous drip, day1 and day8, every cycle is 21 days.Continuous 2～3 cycles;when the chemical treatment is under the way, the trad-itional medicine begin to use.Usage: take orally 3 granule,three times a day,continuous 60 days.Group B:The dose of Cisplatinis 60～80mg/m~2. intravenousdrip in a day or in two-three days.Usage: the dose of Vinorelbine is 25mg/ m~2.intravenous drip,day1 and day8.Every cycle is 21 days.Continuous 2～3 cycles;both regimens were repeated every 21 days for 2～4 cycles . Results:①Theobjective response rates(including CR,PR,NC,PD) ofgroup A and B respectivelyare 0, 0,36.6%,30.0%,60.0%,65.0% and 3.3%,5.0%,P>0.05;②The quality of life,the scores of KPS,the symptom of TCMof group A were improved significant -ly(P<0.05).③Comparing the mostly symptom, analyzed by t test,there is statis-tical difference (P<0.05) between group A and B; The change of taking foodbetween A and B,analyzed by rank sum test,shows that group A is better thangroup B; The variety of the body weight of the two group after the therapy,analyzed by rank sum test,reveals there is statistical difference(P<0.05) betweengroup A and B; Against the side effect of the chemistry treatment, group Ashows the significant superiorities in the aspect of protecting the function ofthe the marrow of bone, alleviating the naupathia and the vomit and reducingto lose ones hair.④There in no significant abnormality in safety indexes likeliver and kidney function in both groups. Conclusion: The study indicates that the improvements of KPS,TCM clinical symptom, appetite and body weight ingroup A obviously surpass the group B.So qijiafuzheng capsule maybe play akey role in the assistant treatment of NSCLC. |
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