| The systemical research was made on asthma through three parts of theory inquiry, clinical observation and animal experiment.In the first part, the literature related to asthma in Traditional Chinese Medicine (TCM) and the recognition of asthmatic etiology and pathogenesis were overviewed, generalized and summarized. For present worse situation of asthma, we emphasized the pathogenesis of breeze-phlegm coexisting, recommended the therapeutic rules of eliminating breeze and removing phlegm.In the second part, the clinical effects of Qufengxuanbifa were observed and its mechanism was explored. 64 asthmatic patients in moderate acute phase were randomly divided into two groups:34 patients were treated with Qufengxuanbi- foumulae as the treatment group, and 30 patients were theated with Dingchuanzhikepian as the control group. The improvements of main symptoms and signs of all patients were ovserved. In the treatment group, plumonary ventilational function (FEV PEF FEV1/FVC) ,the function of small airway( V50 V25.MMEF), airway resistance(Zrs R5,R20), T lymphcyte subgroups (CD4+, CD8+) were measured respectively before and after treatment. The results showed the comprehensive therapeutic effect of the treatment group was correspond to that of the control group (P>0.05) . In the treatment group, after treatment the pulmonary function was significantly improved, the contents of CD4+markedly lowered and CD8+ increased. The clinical research proves that Qufengxuanbi- foumulae is effective complex prescription for asthma, which is valuable for further reasearch and utilizing.In the third part, by means of modern experimental method, observe the Qufengxuanbi- foumulae regulate the balance of Th1/Th2 on bronchus asthmas. The asthmatic models of guinea pigs were established by ovalbumin sensitization were randomized five groups.The levels of the IFN—γ and IL —4 in serum and the pathologic histology of lung were observed. The results... |
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