Pharmacodynamic Study Of The Ssangyong Capsule Treatment Of Bronchial Asthma And Immunology Mechanism

Asthma is a common respiratory disease regarded as one of the four chronic diseases. It considered as a complex disorder characterized by airway inflammation, reversible airflow obstruction and bronchial hyper-responsiveness to various environmental stimuli. In clinic practice, therapy for asthma has the unique challenge of targeting the airways with topical drugs. The two current areas of focus for treatment are anti-inflammatory agents (corticosteroids, anti-cytokines, anti-IgE, anti-adhesion molecules) and bronchodilators (selective b-2 agonists, anti-cholinergics, leukotriene modifiers, phosphodiesterase inhibitors) that interfere with smooth muscle contraction. Considering side effects of corticosteroids , herbal preparations have been cited as the most popular complementary treatment modality by asthma sufferers.Limited by the traditional ideas which herbs can only be used in chronic diseases, traditional Chinese medicine (TCM) is less used in acute asthma. It will be of great importance to improve the effect of TCM on treating acute asthma and understand the mechanism of treating asthma of classical prescriptions.Shuang long (SL)capsule is Chinese drugs preparation based upon an effective medical prescription containing of Ephedra (Herba Ephedra), Chinese Magnoliavine Fruit(Fructus Schisandrae chinensis) and Earth worm (Allolobophora Caliginosa trapezoids) ect. The studies include literature review, demonstration of prescription, pharmacology research and mechanism exploration.1 Literature ReviewWe had reviewed asthma-related literature in home and abroad, including the following aspects: general situation of asthma in TCM and western medicine; development of anti-asthma TCM.2 The demonstration of SL Capsule's prescriptionGuided by TCM's theories, combining with clinical experiences, the prescription of SL capsule is demonstrated by experts.3 Pharmaceutical researchAccording to the differences between water-solubility ingredient and lipid -solubility ingredient and their different actions, we designed the distilling technics which provided the preparation for further pharmacology researches and mechanism exploration.4 Pharmacology researches4.1 Effect of SL capsule on airway hyper-responsiveness in asthmatic animal...