| Objective: To probe into the change of concentrations of serum S100βand interleukin-1 and its clinical significance in patients with multi-infarct dementia(MID) and cerebral infarction (CI). Methods : The concentrations of serum S100βand interleukin-1 were determined by ELISE in 58 patients with MID and 62 with CI and compared with normal control group..Mini-mental state examination(MMSE) was marked to examine the intellectual level of patients ,when elevated 21 score with Hachinski Ischemia Score and DSM-IV and NINCDS—ADRDA diagnosis standard as references. Results: the concentration of serum S100βand interleukin-1 in MID acute episode group were significantly correlation (p<0.05) and were higher than that in MID stationary phase group and that in normal controls(p<0.05)and were significantly higher than that in CI acute phase group respectively on the 24-48h, 7thday, 15thday(p<0.01); ); the concentration of both in MID stationary phase group were significantly highter than that in CI stationary phase group and that in normal controls(p<0.01); both concentration in CI acute phase group were no correlation(p>0.05)and were highter than that in CI stationary phase group and that in normal controls(p<0.05);No difference were found in the expressions of both in CI stationary phase group with that in normal controls(p>0.05);There were no significant correlation between both concentration in blood and MMSE scores in MID stationary phase and MID acute episode group(r=-0.0352,p>0.05;r=-0.0634,p>0.05) . Conclusion: The change of . S100βand interleukin-1 concentration in blood cound dynamically repond the brain functional status in patients witn MID, both were correlation.However both could not directly indicate the intellectual of patients,for both were not intellectual factors. |
