Rhinitis Capsule Of The Efficacy And Acute Toxicity Studies

Objective To evaluate efficacy and acute toxicity of rhinitis capsule so as to provide the scientific proofs of modern pharmacology and medicine security for clinical work. Methods 1 .Pharmacodynamics test:Four groups of animal were tested and there were 40 animals in each group which were randomly divided into four small groups: high dose rhinitis capsule group, low dose rhinitis capsule group, positive control group(biyankang or A.P.C) and vacant control group .They were fed with medicine intragastrically(i.g). The earlap inflammation caused by bimethylbenzene, the effect on pain induced glacial acetic-acid, the influence on the penetrability of capillary vellset in the abdominal cacity and the weight of rat cotton-ball granuloma were observed. 2.Acute toxicity test: Twenty mice were fed with the rhinitis capsule solution of most concentration and volume by intragastrically. All the actions and the appearance of major organs were observed in twenty-four hours and one week. Results 1 .There were significant difference of the earlap inflammation caused by bimethylbenzene, the pain induced glacial acetic-acid, the penetrability of capillary vellsel in the abdominal cavity and the weight of rat cotton-ball granuloma between rhinitis capsule groups and vacant control group(p<0.05) . There was a better effect of high dosage group than the low dosage one. All animals survive the test and there were no abnormal signs and pathological appearances of major organ. Conclusion The rhinitis capsule could relief significantly the earlap inflammation caused by bimethylbenzene and reduce the weight of rat cotton-ball granuloma. It also could put down the penetrability of capillary vellsels in the abdominal cavity and have acesodyne function.