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Powder for Regulating Liver and Spleen (PRLS) is firstly recorded in Shanghan Lun (Treatise on Cold-induced Febride Diseases). It is researched by later doctor of traditional Chinese and generally accepted for original prescription of regulating vital energy. However, there is all sorts of dispute on PRLS, which is lead to long-term contradiction between theory and clinical apply.In the theoretical study of this text, the key mechanism of PRLS was approached through analysis of a number of information with regard to experience and prehension of past dynasties doctor of traditional Chinese. The result was gained as follow.The illness location of syndrome of powder SI NI is mainly in the shaoyin channel. The pathogenesis of it is crown closure of yangqi. The main sign of it is cold limbs in shaoyin disease.The PRLS is combined with Powder ZhiShi ShaoYao (aurantii fructus immaturus and Paeonia) and Herbs grouping ChaiHu GanCao (bupleuri and glycyrrhizae), and its effectiveness is regulating qi to alleviate mental depression. These theory are correlate to later clinical apply.The review of this text was divided to two parts. Analyzing the clinical research of PRLS, we had found that its clinical application was very generally. If the differentiation of symptoms and signs is exact, the curative effect of PRLS is very distinguishing. So, it is generally accepted by doctor of traditional Chinese medicine for an effective prescription. Especially, its distinct predominance in the stubborn disease of circulation system and nervous system is a hot investigative spot.However, there were several deficient in the clinical research of PRLS. First, the rigidity was lack in mostly project. In these research projects, positive control was lack, criterion of diagnosis and curative effect evaluation was not unified, large sample research was few, statistical treatment was few. On account of all these deficient, the degree of confidence was greatly degraded.Second, the mostly clinical research of PRLS was carried out to aim directly at disease and only was simple exploratory development. So, these research were unable to reflect diagnose and treat feature of determination of treatment based in pathogenesis obtained through differentiation of symptoms and signs.Analyzing the empirical study of PRLS, we had found that its prophase study was centered in its effect and protection to digestive system, but some study were excessively simple in mpirical content and technique, and mechanism research was lack. In the recently study, there was a great of breakthrough on PRLS in prevention and cure tohepatic injury and fibrosis, adjustment and protection to nervous-immune system. However, the level of PRLS empirical study was not advanced.Therefore, we proposed several modified suggestion as follow. First, it was wrong that the study on mechanism of action waslimited in certain organ, and we should elucidate the action target and mechanism from cellular level, cytokine level, or gene regulation level. Second, we should elucidate the compatibility method and dose-effect relationship from pharmacokinetics and pharmacodynamics. Third, as one of the best frequently used classical prescription or recipe, we should refine the dosage form of PRLS for clinical request.