| HBV infection is a world-wide problem. It is accounted that there are 350 million chronic HBV infectants in the world, which hit 9th of the human death caused by illnesses published by WHO recently, and prevailed in Asia and Afica especially. Our coutry is a high-incident area of chronic hepatitis which strongly threatened the health of mankind and much attention has been paid to the research of effective treatments. Anti-HBV antibody is lower because of low immunity in chronic hepatitis patients which is not enough to clear out hepatitis B virus inside the body, then lead to a great deal of virus reproduction, continuous liver cell damage, resulted in liver cirrhosis at the end and even turn to liver cancer.Guided by the theory of traditional Chinese medicine, we explored the etiology, pathology and principle of treatment and suggest that hepatitis B is basically caused by exogenous contamination of heat-dampness and epdemic toxin, improper diet, dysfunction of spleen in transporting and transformation as well as, induced by deficiency of Zheng-qi, over fatigue, emotional depression and liver-qi stagnation. The basic pathologic chang is conbination of heat-dampness and epidemic toxin, damage of liver, spleen, kidey, with dampness, heat, qi-stagnation, blood-stasis, epidemic toxin, phlegm (sometimes) as its pathologic factor. As to treatment, we should pay both attion to disease differentiation and syndrom differentiation, mainly clear out heat-dampness and epidemic toxin at acute stage, while support healthy energy to eliminate evils at chronic stage.AIM: To investigate the effect of Yi Qi Qing Gan Fa in treating chronic hepatitis B. METHOD: 80 patients with chronic hepatitis B were devided randomizely into treatment group (40) and control group (40) . The patients in treatment group were treated with Fu Fang Qi Zhu Pian , 4 tablets, TID. While the patients in control group were treated with lamivudine 100mg, QD. Some medicines to protect liver like vitamine and insonine could be used in clinic, but patients cant't be given those medicines influencing immunity or virus reproduction like interferon, thymopeptide, virazole, ect .Course of treatment is half an year, and some patients could be treatmented for one year and all the patients were followed-up by half an year after treatment. RESULTS: Among 40 patients in treatment group, 7 responsed totally (17.5%) , 14 responsed partially (35%) , 19 has no responce (47.5%) , those in control group were 6 (15%) , 16 (40%) and 18(45%) respectively, the general curative effect of treatment group is 52.5% compared 55% in control group (x2 =0.05, P>0.05) ; All the symptoms were improved in treatment group (P<0.05 or P<0.01) , but fatigue and jaudice were improved in control group (P<0.05 or P<0.01) . compared with control group, Fu Fang Qi Zhu Plan has a better effect in improving costalgia, anorexia (P<0.05) ; ALT, AST, GGT, ALP were improved in both groups (P<0.01) and HA, LN, collagen-IV declined varily in both groups (P<0.05) . CONCLUSION: There is no difference between Fu Fang Qi Zhu Pian and lamivudine in anti-virus, improving liver function, anti-fibrosis while Fu. Fang Qi Zhu Pian has a better effect in improving costalgia and anorexia than lamivudine. |
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