Experimental Study Of The Safety And Sugar On The Role Of The Hyperglycemic Animal Models

Objective: to investigate the action and mechanism of antangpill on how to influence diabetic rat's blood glucose blood lipid and improve their disorder state by two different models.Methods:Established DM rats by intraperitoneal injection of Alloxan and Adrenalin are to be divided randomly in five groups:model control,DM model treated with low dosage, middle dosage and high dosage of Antangpill and the west medicine cross-refer respectively.After three week's treatment,detecting rat's following index including BG INS, FMN, TC, TG, HDL, LDL, SOD, MDA, meanwhile rat's pancreatic tissues are also made into pathological section for analysis.Result:DM rats do exist abnormality of the above mentioned index, whose rising blood lipid level is one of important lipid metabolic disorder. Antangpill can improve the DM rat's high blood glucose and blood lipid metabolic disorder, raising INS , HDL content in serum whereas descending TC, TG, LDL; accelerating the repair and protection of the impaired pancreatic cells. The general curative effect of Antangpill is better than the west medicine cross-refer group,Clonclusion:Atangpill can act in multiple ways and levels to descend blood glucose and improve metabolic disorder.