Study On The Relation Of Various Indexes For Evaluating Insulin Secretion And Hyperglycemic Clamp Technique

Objective: In order to study of various clinical indexes, especiallyâ–³INS30/â–³BG30 and HOMA-IS, for evaluating insulin secretion in the deferent of plasma glucose level and insulin sensitivity individual. Use the result of Hyperglycemic clamp technique test as reference to distinguish the accuracy of various clinical indexes.Methods:(1)94 T2DM subjects and 10 nature subjects were respectively T2DM group and control group, they all undergo oral Glucose test,and determine FPG, FINS, PBG30, PINS30. calculateâ–³INS30/â–³BG30 and HOMA-IS. T2DM subjects divided into obese group and non-obese group base on BMI. (2) 30 T2DM subjects and 10 control subjects undergo Hyperglycemic clamp technique, determine the indexes of FPG, FINS, PhlIns, Ph2Ins, MaxIns, PhlMax, Ph2Max,â–³PhlMax,â–³Ph2Max, Ph1MaxTime, Ph2MaxTime. (3)Indexes of insulin secretion of HOMA-IS andâ–³I NS30/â–³BG30 were compared between the T2DM group and control group, between the T2DM obese and T2DM non-obese, and make the analyses of correlation with Hyperglycemic clamp technique conclusion.Results: (1) The result of Hyperglycemic clamp technique in T2DM group were lower than control group, and the result in T2DM obese were lower than T2DM non-obese, both of comparison were significantly different (P<0.05). (2) Compared the indexes ofâ–³INS30/â–³BG3 and HOMA-IS between T2DM and control group, it was lower in T2DM, its was significantly different(P<0.05), FINS in T2DM was higher than in control, the comparison was not significantly different(P>0.05). (3)Comparing between obese and non-obese , PhlIns,Ph2Ins,MaxIns,PhlMax,Ph2Max,â–³PhlMax andâ–³Ph2Max in T2DM,...