| Objective:Observate the effects of GongXieJing(GXJ) which remove blood stasis, stop bleeding, ease inflammation , ease pain and inquire the mechanism of GXJ how it reduces the side effects of drug abortion.Methods: Observate the effects of GXJ which remove blood stasis, stop bleeding, ease inflammation, ease pain and inquire the mechanism of GXJ how it reduces the side effects of drug abortion through the ways of main pharmacodynamics , serum pharmacology, tissue pathology and radiate immunology.Results: 1. The effects of GXJ:GXJ can shorten the time of mice bleeding and solidfing;GXJ can benefit the indexes of blood circulation and variation of rats which are blood stasis; GXJ can reduce the volume of rats' feet and the weight of mice' ears; GXJ can prolong the inubation time and reduce the number of times mice angulate their bodies;GXJ have no obvious effect on shortening the time of mice licking their feet. 2. the mechanism of GXJ :GXJ can increase the intensity and frequency of animal's ureri contraction What' s more, GXJ can benefits drug abortion rats in many aspects:GXJ can accelerate to eliminate the tissue of decidua ;GXJ can benefit to repair pathology change of the uteri tissue and increase the quantity of the uteri smooth muscle; GXJ can shorten the time of PT , PTT , reduce the level of TXB2 , PGF1a, TXB2/PGF1a , P, PRL and raise the level of E2, FSH, LH of the drug abortion rats.Conclusions: GXJ has the effects of invigorating the circulation and removing blood stasis ,hemostasis, easing inflammation and pain; the mechanism of GXJ how it lighten the side effect of drug abortion probable is that it can promote uteri contracting, accelerate to eliminate the tissue of decidua, benefit to repair pathology change of the uteri tissue , increase the stretch fibre quantity of the uteri smooth muscle, strengthen the function of solidfing blood, reduce the level of TXB2 , PGF1a, TXB2/PGF1a, P, PRL and raise the level of E2, FSH, LH. |
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