Clearance Capsules Turp Blood Loss And Prostate Tissue, Blood Vessels Form The Mechanism Study

Objective: To evaluate influence of Tongguan Capsule on bleeding during TURP on BPH patients and study mechanism of it inhibiting bleeding during TURP through the point of vasculogenesis on BPH.Methods: 39 BPH patients, having surgery sign, were randomly divided into 3 groups-Tongguan Capsule group, finasteride group and placebo group with each group having 13 patients according to hospitalizing orders. TURP were operated and general bleeding volume, bleeding volume per gram and bleeding volume per minute were calculated after 2 weeks of administration. Expressions of AC 133 antigen, KDR and HIF-1 were studied in prostatic tissues in all groups (including normal group) by immunohistochemistry and image analysis system.Results: General bleeding volume, bleeding volume per gram and bleeding volume per minute in both Tongguan Capsule group and finasteride group decreased significantly compared with those of placebo group (P<0.05). The results of immunohistochemistry and image analysis system manifested that expressions of AC 133 antigen, KDR and HIF-1 in hyperplastic prostate of placebo group significantly increased compared with those of normal group,at the same time,those of both Tongguan Capsule group and finateride group significantly reduced compared with those of placebo group(P<0.05 or P<0.01).Conclusions: BPH is related to vasculogenesis. Tongguan Capsule can reduce bleeding during TURP. The principle is possible related to inhibiting Expressions of AC 133 antigen, KDR and HIF-1 in BPH and then inhibiting vasculogenesis.