Clearance Of The Experimental Study Of The Effect And Mechanism Of The Capsule Of Benign Prostatic Hyperplasia

Objective: to evaluate efficacy of Tongguan Capsule on experimental benign prostatic hyperplasia (BPH), and to explore its mechanism. Methods: firstly, SD rice were made into BPH models by peritoneal injection of test-osterone after having been castrated. Morphologic changes of prostatic tissues in all groups were studied by morphometry. MVD (microvessel density) and Expressions of bFGF, VEGF, endostatin, MMP-2 and TIMP-2 were studied in prostatic tissues in all groups by immunohistochemistry and image analysis system. Secondly, trigone muscle strips of rabbit urinary bladder are taken and induced to contract by NE, the inhibition action of Tongguan capsule is observed. Results: Tongguan Capsule can reduce the prostatic volume of BPH rice, including gland and stroma. It can decrease the MVD of prostate, inhibit expressions of bFGF, VEGF, MMP-2 in prostate, and decrease expression of, endostatin, TIMP-2 in prostate. It can also resist the contracion of trigone muscle strips of rabbit urinary bladder induced by NE. Conclusions: Tongguan Capsule has a good effect on experimental BPH. On the one hand, it can decrease prostate size to remit the statics factor of BPH. The mechanism maybe relate to regulate the correlation factors of angiogenesis in prostate and inhibit the prostatic angiogenesis of BPH. On the other hand, it can resist a 1AR of trigone muscle of urinary bladder to remit the dynamic factor of BPH...