Compound Notoginseng Injection Quality Standards And Pharmacodynamic Study

Heart cerebrovascular disease is one of chief enemies of beings. To fit clinic,we plan to develop "Fufang sanqi injection" according to traditional Chinese medicine theory. The prescription is made up of radix notogiseng and kudzuvine root. Us effect is promoting blood circulation and detoxicating. It is used in brain theombiis and sequelae by YingWeiQi disorder or torin injuring center colluterals,with arthragia and unconciousness. The vein injection effects quikly to whole body and is the best to enmmergency.We search a qutity of documents about radix notogiseng and its preparption of lately ten years and summarize its reseaeching evolution about chemical ingredient qualitative analysis methods* pharmacology and clinical usage.The problem has two parts, including drawing up of the quality standard and examination standard of fingerprint and major oharmacodynamics of "Fufangsanqi injecting".The first of the test,we draft the quality standard of radix total saponin, and control their contents with radix notogiseng saponin RI, ginseng saponin Rgb ginseng saponin Rbi according to standard of nation WS3-B-3590-2001 (Z) .Subsequently we draw up the quality standard of "Fufangsanqi injection". The item of distinguishing has a good effect with TLC method according to pharmacopoeia of People's Republic of China (1st section of 2000 version,10). In the determining content,we plan to limitate three saponins' content to ensure its effectiveness .The sencond of the test,we peotect neuron through repress cerebral paralysis ischemia cascade reaction and improve brain subtle flow aiming cool blood and detoxicat and invigoratchannels whth a cerebeal chemia pattern of big mouses middle cerebral artery thrombosed by FeCl3. And we demonstrare that "Fufangsanqi injection" improve obviously these symptom in psychoneurosis, brain containing liquid and hemorrheology. To prove gharmacodynamics effect, we compare with positive drug "Xueshuantong injection". "Fufangsanqi injection" is used with smaller dose while the same effect than "Xueshuantong injection". We achieve to purpose of attenuation and increasing curative effect ,...