The Relationship Between The Recurrence Of Benign Meningioma, And Proliferating Cell Nuclear Antigen (pcna) And Bcl-2 Gene Expression

Objective Meningiomas are principally benign in nature. Some meningiomas, however,grow fast or recur even after total removal. The biological behavior of meningiomas often can not be predicted from convent i onal histopatho IogicaI studies. We use a monocIonaI antibody against proliferating cell nuclear antigen(PCNA) and the expression of be 1-2 to investigate the usefulness of the PCNA label ing index and be 1 -2 as a parameter to predict the recurrence of benign meningiomas.Methods We examined the expression of be I-2 and PCNA by PV-9000 i mmunoh i stochem istry in 60 specimens of benign intracraniaI meningiomas .All of the cases were divided into two groups: recurrence(group 1),non-recurrence (group 2).The patient included 26 men and 32 women, mean age 48.38(range 14 ⁷5)years.Ninety of the 58 primary tumors recurred locally. The mean progression-free follow-up period for patients without tumor recurrence was 6.5 years.Results Analysis of variance revealed that significant differences existed between the two groups for both PCNA LI (17.53%?.93% (x^-眘) for group!, 3.25%?.87% for group2) and expression of be I-2 (67% for group!, 26% for group2) (p<0.01) .There is a significant difference existed between bc1-2 positive and negative groups,for PCNA LI (11.77%?.85% for bc1-2+, 5.9% ?.34% for bcl-2? (p<0.01) .The bcl-2 positive group included 14 cases i n group 1 and 10 cases i n group 2. A s i gn i f i cant d i f ference a I so ex i st between group 1 and group 2 for PCNA Ll(17.06%?.64% in group 1,4.37%?.71% in group 2) (p<0.01) .A similar trend was found for PCNA LI in group 1 higher than in group 2.Conclusion Both PCNA LI and the expression of bcl-2 has a good correlation with the recurrence of benign intracranial meningiomas. PCNA LI and the expression of bcl-2 on recurrent meningiomas were higher than non-recurrence ones. The whole of the two markers considered in benign intracranial meningiomas does predict recidivism..