| Protective effects of arrhythmia and myocardial ischemia of Mongolia Medicine ZDK were studied, meanwhile, the safety was also described in this paper.Results of protective effects on myocardial ischemia showed that ZDK of three dosages not only prolong the mean survival time under ordinary pressure, the disappearance time of electrocardiographic sign after clamping the trachea in mice, but also obviously ameliorate acute myocardial ischemia induced by isoprenaline in rats, increase SOD activity and reduce the level of MDA on myocardium. T wave changes in ECG by pituitrin were retarded, decrease of HR was prohibited in rats. The infarct range on acute myocardial ischemia in canines was significiantly decreased. ZDK could obviously increase the coronary arterial blood flow, decrease total coronary arterial resistance.so as to improve myocrdial blood andoxygensupply.Meanwhile, ZDK had the effects on reducing utility ratio of oxygen and the amount of myocardial oxygen consumption. ZDK could increase the serum NO levels,decrease the plasma ET levels markedly in canines.The antiarrhythmic results showed that ZDK significantly decreased the incidence of VF induced by chloroform in mice and the time of VF induced by barium chloride, antagonized the arrhythmias induced by aconitine and coronary occlusion in rats . ZDK could increase the threshold of electric stimulation-induced VF in rabbits.Meanwhile,in hemorrheology study ,thedata indicated the whole blood high-shear and low-shear viscosity, whole blood reduced viscosity, erythrocyte aggregation index ,erythrocyte rigidity index,and erythrocyte emigration time were decreased. ZDK could effectively prolong the sleeping time induced by pentobarbital sodium in rats. Safety experiment showed that the largest i.g amount of ZDK were 108g/kg in mice. Safety experiment of three months in rats found no poisonous effects. |
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