A Study Of The Relationship Between Myocardial Ischemia And Hypoxia And Ventricular Arrhythmia

Ventricular arrhythmias originate below the atrioventricular node inthe ventricular myocardium or His-Purkinje system, characterized byventricular rhythm disorder. These include ventricular premature beats,nonsustained and sustained ventricular tachycardias, Ventricular flutter andventricular fibrillation. The last two are malignant arrhythmias that occurbefore death, while the former two can be seen in normal people or patientswithout structural heart disease, and also seen in severe heart diseases,often act as a precursor for the malignant arrhythmias. At present, the mainmechanisms of ventricular arrhythmias are triggered activity, abnormalautomaticity and reentrant excitation, but the exact details is not clear.Many clinical studies have found that the incidence of ventriculararrhythmias increased significantly when combined with sleep apneasyndrome, myocardial infarction, heart failure, pulmonary heart disease. Itisn’t difficult to find that myocardial ischemia and hypoxia can increase theincidence of ventricular arrhythmias by the three main mechanisms, thespecific mechanisms may be the abnormal regeneration and distribution of autonomic nerve, the abnormal activity of the autonomic nervous, theabnormal structure of electrical conduction, the abnormal ion channelactivity of myocardial cell membrane, etc. Therefore, we can increase theperipheral blood’s oxygen concentrations and reduce the myocardialoxygen consumption to change the state of myocardial ischemia andhypoxia, in order to achieve the purpose of reducing the occurrence ofventricular arrhythmias.