| Infection of billiary tract is a common disease of surgical department. The morbidity of this disease tends to be increasing gradually with the changes of people's diet structure, the fastening of people' s life rhythm and the aging of the population in recent years. The disease is manifested by many complications with two different situations: one is chronic which is lingering difficult to cure; anther is acute which flare up quickly, develops quickly and even can endanger one's life.Biliary tract infection is mainly caused by the factors below: First is the infection of bacteria including aerobe and anaerobe; Second is relevant to billiary tract obstruction; Third is relative to billiary tract stone; Forth is relative to infectious route such as blood, lymph, retrograding, introgenic factor and so on; Fifth is the infection of parasites; Sixth is the susceptibal factors of body such as aging, women, diabetes, hepatocirrhosis and so on.I introduce the treatments on this disease in western medicine presently. First is conservative to use anti-bacteria treatment with treating the symptoms. It can relieve the symptoms temporarily, butdisease will repeat for many times (It is believed now there a^ jjo bacteria infection in the early stage of infection of bijjftry tract in most circumstances and antibiotic can not stop the development of the disease completely for satisfied result). Second is outside treatments such as resolving the stones, crashing the stones, withdrawing stones by surgery, withdrawing stones by abdominoscopy and so on with the defects of expensive costs, great damage to liver function and body, many precautions and complications.The western treatment is often difficult to accept for constrains of body constitution, many and severe complications, high recurring rate after surgery and sp on. In contract, traditional Chinese medical treatmentcan not only control bacteria infection and relieve inflammation, but also change components of bile, improve immune function of whole body, protect liver function so that it is very important on conservative treatment or peri-surgical period treatment on infection of biliary tract. In the field of experimental study of traditional Chinese treatment on infection of biliary tract, several aspects below were focus on: to study anti-inflammatory and defervesce mechanism of traditional Chinese medicine by detecting PGE, camp, TNF and so on by radioimmunoassay; to check the flux and ingredients of bile by bile drainage; to certify the effects of normalizing the function of gallbladder of traditional Chinese medicine by measurement muscle tension of O ddis's sphincter; to study the effects of anti-bacteria and anti-endotoxin of TCM. Zhengshi decoction of relieving inflammation and normalizing the function of gallbladder is a clinical experimental formula of professor Zheng Zetang in acute abdomen research center of Guanzhou university of TCM. The prescription has many effects such as clearing away liver-heat and normalizing the function of gallbladder, removing abdominal heat and smooth the organs' qi, promoting blood circulation to remove blood stasis and so on to treat acute/chronic cholecystitis, bile ducts inflammation, ascariasis of biliary tract et al with satisfied results. Our experiment is the preparatory study of the prescription on anti-inflammation, liver function protection, liver pathology and so on. In the experiment, 24 female SD rats were divided to four groups in random: A is negative control group (model group), B is traditional Chinese medicine group, C is Ofloxation group, and D is false surgery group. In group of A, B, C, threads was used to ligate the common bile duct, then O.lml Escherichia coli was injected at proximal position of common bile duct to induce the animal model of infection of biliary tract; In group D, we only do abdominal section. After surgery, rats in each groups were fed equally; drugs were given by oral 8 hours after4surgery for the first time (once /12h): Rats in A group were given 4ml contracted... |
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